Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Antimicrobial resistance is one of the biggest threats to human health worldwide in the coming decennia.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

This interdisciplinary study focuses on (trans)national ethnic and popular networks, combining historical-ethnographic and computational methods to understand the ‘workings’ of networked conflict interfering in the increasingly violent conflict in the Sahel (Africa) and beyond. The project focuses on…

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

From the virtuosic songs of a nightingale to the various alarm calls of a great tit, bird sounds are incredibly diverse. They are among the most complex sounds in the animal kingdom and, according to Darwin, resemble language more closely than the vocalisations of other animal groups. But what do we…

Festival

Graduation Ceremony

Toward optimal measurement and greater understanding of youth cognition in school refusal and cognitive behavioural therapy outcome

In this article, Chiara Anfuso, Andrea Bartolucci, Cristina del Real, and Sanneke Kuipers examine cyber threats in humanitarian aid, exploring how digitalisation increases vulnerability and assessing the challenges organisations face in strengthening cybersecurity and response strategies.

In this book, Jan Melissen and other authors explore how governments engage domestic citizens in global affairs through the emerging practice of 'home engagement' in diplomacy, highlighting its growing importance in an interconnected and politically turbulent world.

To overcome the limitations of slow and error-prone quality control, this research develops an advanced 3D imaging method for the rapid and reliable detection of internal defects in critical sectors.

The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.

The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.

The Public Entities of Saba and St. Eustatius commissioned two landscape biographies at the Dutch Cultural Heritage Agency (RCE).

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

This thesis comprises four closely related interpretative studies and set out to answer the compound question: ‘How do teachers interpret their classroom interactions in terms of their pupils’ best interest?’

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

All the data stored and processed by our computers is encoded as sequences of zeros and ones, called bits. Quantum computers offer an alternative to this traditional way of encoding and manipulating information.

Anionic particles play an important role in biological systems where they fulfil many essential functions for cells.

This thesis examines strategies to address the global threat of antimicrobial resistance (AMR). Antimicrobial resistance poses an increasing global health risk, highlighting the need for new treatments against Gram-negative pathogens.

On Tuesday 30 April 2024 Jonny Russell successfully defended a doctoral thesis and graduated.

Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.

Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.

Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.

In this article, Sanneke Kuipers and Machiel van der Heijden examine how patterns of policy inaction emerge in public organisations, arguing that systematic biases and organisational decision premises contribute to the failure of policymakers to address pressing societal issues.

Conference

Amsterdam painter Dirk Valkenburg (1675–1721) produced some of the earliest depictions of Indigenous and enslaved people on Surinamese sugar plantations – idealized images that conceal the violence of colonialism.

In this article, Barrie Sander, Assistant Professor of International Law, adopts a narrative theoretical lens to examine how security is constructed, contested, and narrated within three EU regulatory frameworks at the intersection of climate and AI governance - the Critical Raw Materials Act, the AI…

This book addresses the definition of history and how people are influenced by it.

Study information

Conference

Jelena Vićić and Richard Harknett offer an analytical construct to better understand the mechanism by which cyber-enabled influence operations work

This project investigates how people choose linguistic forms like questions or statements in everyday speech.

This project investigates how inhabitants of Leiden with a migratory background experience the extent to which their language and cultural background is welcomed in Dutch society and how this affects their identity, sense of belonging, and general wellbeing.

Workshop

In this research we have studied how teaching graphing formulas by hand (i.e. sketching a graph of a formula) could promote grade 11- and 12-students’ symbol sense.

Study information

Insights in diet, climate and ecology

How do humans, non-humans and their interactions and relations shape the home as ecological and social space?

When we read a text, we think we know who wrote it, but in the early modern period, manuscript production was often a collaborative or ‘socialised’ enterprise involving secretaries and scribes who physically wrote what the author dictated.

, Sandifortdreef 21, 2333 ZB, Leiden

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The role of language in self-regulation and social behavior in children with an extra X chromosome

The use of Artificial Intelligence (AI) to optimize Magnetic Resonance Imaging (MRI),