Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

Holtz defended her dissertation ‘Collective human rights as an (onto)logical solution to climate change: reconceptualizing, applying and proceduralizing an overlooked category of human rights’ on 16 October 2025. The doctoral research was supervised by Carsten Stahn and Daniëlla Dam-de Jong.

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

The Excellence of the Arabs is a spirited defense of Arab identity—its merits, values, and origins—at a time of political unrest and fragmentation, written by one of the most important scholars of the early Abbasid era.

The narrow but long stretched stript of Frisian land along the North Sea was already occupied before Roman times. However, man repeatedly suffered setbacks when he tried to extend his living space, both in the tidal marshes and the peat area south of them.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Despite the elaborate equality and non-discrimination legislation in the European Union (EU), the current legal framework has been widely deemed ill-suited to properly address discriminatory instances that may emerge from the use of algorithms and Artificial Intelligence (AI) technologies. Nevertheless,…

The thesis explores micromammal fossils from the Afşar section in Anatolia, a crucial locality for understanding the Pliocene epoch and the transition to the Villafranchian Age.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

This report examines the questions

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Ruobin Han defended her thesis on 21 March 2017

The Genius of Invective is a peerless example of the breadth, depth, and complexity of the Arabic classical literary tradition. It was once one of the most popular works of Arabic literature, read across all regions from Mauritania to India, from Istanbul to Zanzibar. This volume marks the first English–Arabic…

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotor: A. Kros

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Hekmat Dirbas defended his thesis on 14 February 2017

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: Dr. M. Haverkorn

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

A Twenty-First Century Guide

In this journal article, Dr. Joris Larik and Dr. Richard Ponzio put forward a broad-based pandemic recovery agenda that goes hand in hand with institutional reforms at the global level.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

On 24 January 2024, Vethaak defended the thesis 'Empirical Analysis of Social Insurance, Work Incentives and Employment Outcomes'. The doctoral research was supervised by Koen Caminada and Pierre Koning.

This article provides a behavioral perspective that examines responsibility attribution to the national government (upward) and policy implementers (downward) as a function of performance relative to decision-makers' aspiration levels. The study proposes that perceived accountability increases the propensity…

In this article, Dimitrova, Gürkan and Koops presents a general framework for capturing and systematicallyanalysing critical junctures and degrees of change in EU policies.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

On 23 April, Andreas Häuselmann defended the thesis 'EU privacy and data protection law applied to AI: unveiling the legal problems for individuals'. The doctoral research was supervised by Gerrit-Jan Zwenne and Bart Custers.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

On 18 December 2019, Marianne Lochs defended her thesis 'Contempt of court'. The doctoral research was supervised by Prof. C.P.M. Cleiren and Prof. J.H. Crijns.

De incubatietijd (van infectie tot de eerste symptomen) en latente periode (van infectie tot de start van besmettelijkheid) zijn cruciaal voor het informeren van controle maatregelen aan het begin van een infectieziektenuitbraak. Een voorbeeld is de duur van quarantaine voor potentieel geïnfecteerden,…

In this project, we use social network analysis to analyze the behavior of users in online forums and associated marketplaces over time.

Firearms and violence in Europe–A systematic review by Katharina Krüsselmann, Pauline Aarten, Marieke Liem

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Promotor: M. Ubbink, Co-promotor: G. Siegal

On 25 November 2020, Sara Arendse defended her thesis 'De uiterlijke verschijningsvorm in het strafrecht'. The doctoral research was supervised by prof. C.P.M. Cleiren and prof. J.M. ten Voorde.

On 22 June, Chalermwut Sriporm defended the thesis 'Franchising legal frameworks: a comparative study of the DCFR, US law and Australian law regarding franchise contracts'. The doctoral research was supervised by Jacob Hijma and Iris Houben.

Reading emotions from others’ faces strengthens social relationships. But how is that for children with hearing loss? Can they learn to read faces just as easily as hearing children? The study by Yung-Ting Tsou and colleagues shows that daily

Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…

On the 16th of May, Qing Yang successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Qing on this achievement!

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

In this article, Lianne Visser contributed to the understanding of why collaborative governance is a challenging response to wicked problems.

Languages of The Hague is a collection of columns on languages and language which were published between 2016 and 2018 in the weekly newspaper Den Haag Centraal.

On 12 March, Frederik Heitmüller defended the thesis 'Combatting tax avoidance, the OECD way? The impact of the BEPS Project on developing and emerging countries’ approach to international tax avoidance'. The doctoral research was supervised by Madeleine Hosli and Irma Mosquera Valderrama.

Agrian History, 5300 BC - AD 1000; C.C. Bakels

As Bolivia reels from the collapse of the government in November 2019, a wave of social protests, and now the impact of Covid-19, this book asks: where next for Bolivia?