Mechanisms fro drug resistance

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Discovery of metastasis promoting candidate drug targets

Carsten de Dreu has received the Carol and Ed Diener Award in Social Psychology which is designed to recognise a mid-career scholar whose work has added substantially to the body of knowledge to the social psychology field and brings together personality psychology and social psychology.

Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

In an appeal case, an employee of a care organisation in Nijmegen who was shown the door because of her criticism about the coronavirus voiced on LinkedIn, has had her dismissal reviewed. The court in Arnhem ruled that the employee had crossed a line and that her employer was entitled to dismiss her…

What insights do eleven social Facebook-accounts of Dutch and Belgic foreign fighters offer with respect to the phenomenon of so-called returnees?

From 23-25 April 2014, a conference will be held on the topic of Buddhism and Social Justice. This conference confronts the common perception of Buddhism as intrinsically a tradition of peace and justice, and explores the various ways in which historically Buddhist societies of Asia have shaped, transmitted,…

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

Exclusion elicits the same response in children as in adolescents and adults. That is what psychologist Mara van der Meulen found when she studied brain activity in primary schoolchildren. ‘What is new for us is that it is the same in childhood as later in life.’ Doctoral defence on 10 December.

Organizations often announce their protest activities prior to their implementation to mobilize awareness, recruit supporters, and receive media attention. We are interested in the effectiveness of protest announcements—that is, under what conditions governments make concessions to avoid having an announced…

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Comparing terrorist attacks with falling off a step ladder is absurd, writes Jeanine de Roy van Zuijdewijn in NRC Handelsblad on 27 September 2017.

Thanks to data science, we can chart and search enormous quantities of related information. This generates all kinds of new insights, for example in complex global financial structures or such societal problems as loneliness.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

It was already known that social anxiety disorder often affects more than one person in the same family. But research by PhD student Janna Marie Bas-Hoogendam has now shown that there are genetic brain characteristics that are associated with social anxiety. The PhD ceremony will take place on 14 Ja…

Bleda Düring was interviewed alongside researchers working on ancient religions and primates, for an article in the Swiss magazine bref on the emergence of social inequalities. Although perspectives on the rise of social inequalities differ between these researchers they all agree more research on how…

This study focuses on the local level impacts of a highly globalised industry: the international trade in tropical timber.

Shyness is perfectly normal, Michiel Westenberg stated in his farewell lecture. But that doesn’t mean that social anxiety shouldn’t be identified and addressed in good time. ‘Serious shyness has strong genetic roots; you don’t just get over it.’

Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…

In the specialisation Occupational Health Psychology, part of the Master in Psychology, you will integrate knowledge of several disciplines in psychology, with a clear focus on workers and their work setting.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Cell adhesion signaling

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

This article explores how to think about solidarity, considering the diverse stories, spaces, practices, bodies, and temporalities that shape a city.

Negative perceptions of ambiguous social cues, social performance and physical arousal in socially anxious youth

The interdisciplinary programme Social Resilience & Security is inviting proposals for seed funding. The programme aims to combine knowledge and expertise from five different faculties to study transgressive behaviours, its dimensions, aetiology, and effects of interventions with a multidisciplinary…

As a student in Security Studies you are a socially engaged critical thinker eager to study real-life security cases in an academic setting. You focus not just on the broad context of these issues but also on the role of government, institutions and media. Want to know more? Sign up for one of our Open…

With this podcast series 'Introduction to Security Studies', you will get to know more about the bachelor's programme Security Studies at Leiden University in The Hague and life as a student in The Hague.