Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

In several Mediterranean regions archaeological sites have been mapped by fieldwalking surveys, producing large amounts of data. These legacy site-based survey data represent an important resource to study ancient settlement organization. Methodological procedures are necessary to cope with the limits…

Doctoral Thesis

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

On 30 September 2021 Babette van Hazebroek defended her thesis 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. The doctoral research was supervised by Prof. J.W. de Keijser and Prof. A. Popma (VUMC).

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

This dissertation provides a grammatical description of Ghomara Berber, a Berber language spoken in North-West Morocco by about 10.000 people. The grammar consists of a description of the phonology, the morphology and the syntax. In the appendices a number of texts and a wordlist are included. The data…

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Mr. Jan van den Berg defended his thesis on 8 November 2018

Irene Morfini defended her thesis on 21 February 2019

The Phantom of the Ego is the first comparative study that shows how the modernist account of the unconscious anticipates contemporary discoveries about the importance of mimesis in the formation of subjectivity.

Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal

Vaccination via the skin or the mucosae

Robert Pee, William Michael Schmidli (Eds.) This book posits that democracy promotion played a key role in the Reagan administration’s Cold War foreign policy.

The socio-political and cultural memory of the Achaemenid (Persian) Empire played a very important role in Antiquity and later ages. This book is the first to systematically chart these multiform ideas and associations over time and to define them in relation to one another, as Persianism.

In this book, Sarah Giest, Assistant Professor at the Institute of Public Administration, provides insight into the collaborative and absorptive capacities needed to provide public support to local innovation through cluster organizations.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Comparing Mycenaean tomb building with labour and memory

Psycho-physiological reactions to stress.

Paisaje, cerámicas e interacciones

Do objectively correct solutions to ethical dilemmas exist? Or is ethics always a matter of your opinion against my opinion? How do you know what to do? What kind of thing is ethics anyway? Can you be an expert in ethics?

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Aristotle's Poetics: the oldest and most influential work of western literary theory.

How do people experience ‘inclusion’ in sports? How can experiential expertise enhance policies in sport and inclusion? This research internship at The Mulier Institute enables a student to investigate these issues from a qualitative research perspective.

Promotor: S.M. Verduyn Lunel

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.

Previous studies have identified institutional, organizational, and individual factors that promote innovation in public organizations. Yet they have overlooked how the type of public administration—and the type of administrators—is associated with innovative attitudes.

Addressing loneliness faced by students with special needs and aiming to sense the dynamics and perceptions of students during unstructured school time.

This is the first special issue of any organisation studies journal on food labour. Why is this a big deal? In this Introduction, we argue that the field should pay much more attention to the agri-food system and the work that goes into producing, distributing and consuming foodstuff. Food is such an…

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Promotores: H. Schiessel, G.T. Barkema

On Thursday 15 December, Elisavet Alexiadou has defended her doctoral thesis ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece.’ at the Academy Building of Leiden University. Supervisor was Prof.dr. A.C. Hendriks.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

To what extent are the rights to street children violated en how can their rights be protected?

On 28 January 2021, Dorine Verheij defended her thesis 'Credit rating agency liability in Europe'. THe doctoral research was supervised by Prof. M. Haentjens and Prof. A.G. Castermans.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri