On Friday 22 November 2024 Ye Jiang successfully defended a doctoral thesis and graduated.

The illicit trade in stolen cultural property is booming. Countless works of art and antiquities will be lost if we don’t do more to stop this. This is what experts warned at a Leiden Global congress at the National Museum of Antiquities.

On the 26th of September, Cosmas Rai Amenorvi successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Cosmas on this achievement!

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

An archaeological case-study of the Pointe des Châteaux, La Désirade and Les Îles de la Petite Terre micro-region, Guadeloupe, F.W.I.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

This article by Honorata Mazepus and Florian van Leeuwen in the journal Governance: An International Journal of Policy, Administration and Institutions looks at how evaluations of authorities were influenced by four aspects of a governmental response to a hypothetical disaster.

How do Humanitarian Response Organizations (HROs) and Virtual & Technical Communities (V&TCs) collaboratively govern disaster sensemaking processes, and what challenges shape the effectiveness of these collaborations between 2010 and 2016?

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

This dissertation defends the existence of a type of movement that has so far been considered not to be possible, namely, movement of a bare head to a specifier position over arbitrarily long distances.

Organised in four separate sessions throughout the day, and broadcast live online to guests and families who could not join, a total of 260 students received their Bachelor’s Diploma of International Studies on 28 August 2020 at the graduation ceremony in the historic Pieterskerk in Leiden.

The Leiden municipality wants to make the city centre climate-proof and combat heat stress by greening it. But they want to do this in a way that does justice to the city’s heritage. Researcher Fenna IJtsma delves into historical greenery to offer inspiration.

For her research, PhD candidate Liselore Tissen put one famous painting after another through a 3D scanner. The resulting reproductions were indistinguishable from the originals. But what does this mean for our interpretation of art?

The Security Studies bachelor's programme has received a bronze medal in EW Best Studies 2023. Every year, EW Best Studies selects the top programmes in Dutch higher education.

This study aims to examine how South Korea (hereafter, Korea) and Japan, two neighboring countries in Northeast Asia, have been responding to and mitigating the spread of COVID-19.

Organised in three separate sessions throughout the day, and broadcast live online to guests and families who could not join, over 200 students received their Bachelor’s Diploma of International Studies on 3 September 2021 at the graduation ceremony in the historic Pieterskerk in Leiden.

On Friday 16 May Juul Eijk successfully defended a doctoral thesis and graduated.

Graduating in international law and fulfilling a childhood dream by performing your own theatre show. Alumna Fleur Verhoeff has achieved both. How did she go from studying law to the performing arts? And how does her background in international law help?

Lecture, Roundtable Forum

Lecture

Historians recently started preliminary research on Leiden University’s role in colonialism and historical slavery. Our knowledge about this is too limited and fragmented. They are looking with fresh eyes at Leiden’s archives and collections. An interview with historians Alicia Schrikker and Ligia G…

This research aims to investigate how different social forces interact with hydropolitics in the Eastern Nile Basin and what are the constraints of engagement.

Understanding others’ emotional behavior is essential for navigating daily social life. But how is such an understanding achieved? The eye-tracking study by Yung-Ting Tsou and colleagues shows that children with hearing loss adopt a unique visual strategy that makes uses of explicit visual information…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

The third project, worked on by dr. Rina Knoeff, is a synthesising project directed at studying the Leiden anatomical collections as important parts of ‘public history’. It will use the results of the other projects in order to analyse anatomical collections (their focus, significant silences, audiences,…

1) How natural cycles and activities are interconnected for building the time in one community? 2) What perceptions of Ñuu Dzaui peoples about their landscape can be connected with precolonial times?