The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

What makes a good historian? When historians raise this question, as they have done for centuries, they often do so to highlight that certain personal attitudes or dispositions are indispensable or studying the past. Yet their vieuws on what virtues, skills or competencies historians need most differ…

The thesis presents a new perspective on Giovanni Girolamo Kapsperger (ca.1580-1651), who is nowadays only famous for his works for theorbo and lute, his remarkable output of vocal music of all genres being still mostly neglected from musicologists and performers.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The aim of this research is the systematic analysis of the wisdom coined by Nahua people of Mexico, based on the historical sources and archaeological evidence, but also in the knowledge developed by contemporary indigenous communities and the contributions of indigenous scholars.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Researchers have been working for centuries in mapping the human brain. But in the year 2017 some brain structures remain still not well mapped, especially those located at the brainstem. In this paper, we quantified the test–retest reliability of imaging the brainstem nucleus locus coeruleus in vivo…

Osteoarchaeology is a rich field for reconstructing past lives in that it can provide details on sex, age-at-death, stature, and pathology in conjunction with the cultural, social, and economic aspects of the person’s environment and burial conditions. While osteoarchaeological research is common in…

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Harry’s research work looks at the techniques and influence of chordal and polyphonic accompaniment on viola da gamba in the sixteenth century.

Nobuaki Murai defended his thesis on 24 January 2018.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

This book discusses theories of crisis management and the radical right, to shed light on how responses to crisis influence radical right parties in their presence, discourse, and evolution. The book offers a comparative perspective by examining case studies with various traditions of radical right…

In this research project Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).

Snellius, Niels Bohrweg 1, 2333 CA, Leiden

Historical geo data are gaining in importance. Provided that they are exactly geo referenced, they can be stored into a GIS and thus be combined with all kinds of maps (topographical, pedological, etc.) and datasets. This makes it possible to analyze historical developments in space and time on a detailed…

This volume provides an authoritative, cutting-edge resource on the characteristics of both technological and social change in warfare in the twenty-first century, and the challenges such change presents to international law.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

On 13 September 2017, Tess de Jong defended her PhD Thesis: 'Procedurele waarborgen in materiële EVRM-rechten'. The supervisors are prof. mr. T. (Tom) Barkhuysen and prof. mr. Y.E. (Ymre) Schuurmans.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Tactile Paths is an artistic research project that aims to expand and articulate the feedback between notation and improvisation in experimental music.

Roman Nijmegen is not only the largest archaeological micro-region in the Netherlands, but also one of the most extensively excavated settlement complexes of the Roman period north of the Alps.

FSW building, Wassenaarseweg 52, 2333 AK, Leiden

In the globalised world of today, traditional definitions of national Self and national Other no longer hold. The unmistakable transformation of German and Dutch societies demands a thorough rethinking of national boundaries on several levels.

During times of domestic turmoil, the use of force abroad becomes an appealing strategy to US presidents in hopes of diverting attention away from internal conditions and toward a foreign policy success.

This research proposal focuses on the investigation of the poetic potentials of negativity through the exploitation of failure in sound based artistic practices - a context that has not been extensively addressed.

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

Is criminal disenfranchisement compatible with a democratic political order? This article considers this question in light of a recently developed view that criminal disenfranchisement is justified because it expresses our commitment to democratic values.

European Border Communities provides an overview of interdisciplinary research on the dynamics, challenges and effects of cross border mobilities and the management thereof.

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

RaMa-Scene is a web-application to create and analyse circular economy scenarios using Multi-regional Environmentally Extendend Input-Output Analysis.

This project explores how national research evaluation systems influence research content. Addressing past methodological and causal analysis issues, it applies a new approach to identify these effects. CWTS will oversee Dutch case studies.

Studies in current archaeological applications of remote sensing and non-invasive prospection methods edited by Hans Kamermans, Martin Gojda and Axel G.

The subject of the research is ‘difference and repetition’, an area which bears a direct relationship to Wjm Kok’s practice, in which the production of work always emerges and passes through series.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

What Determines Perceptions of Bias toward the International Criminal Court? Evidence from Kenya. In this article, published on the website SAGE Journals in the Journal of Conflict Resolution, the authors Geoff Dancy, Yvonne Marie Dutton, Tessa Alleblas, Eamon Aloyo examine the attitude towards international…

Across Europe, new welfare programs exemplify attempts to govern through community. This article asks how such governing through community is done in practice. Drawing on comparative insights from fieldwork with parenting support professionals and volunteers in Amsterdam, Milan, and Paris, we document…

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Promotor: Prof.dr. H.A.G. Wijshoff

Sociopragmatics is a rapidly growing field and this is the first ever handbook dedicated to this exciting area of study.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

On the 18th of June, Abel Warries successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Abel on this achievement!

Antoaneta Dimitrova, Professor Comparative Governance at Leiden University, Honorata Mazepus, Assistant professor at Leiden University and Dimiter Toshkov, Associate Professor at Leiden University, together with three other authors researched which aspects of state capacity might contribute to opening…

On 31 January 2018 Vestert Borger defended his dissertation entitled ‘The Transformation of the Euro: Law, Contract, Solidarity’. The dissertation has been written under the supervision of Professor Stefaan Van den Bogaert (supervisor) and Dr Jorrit Rijpma (co-supervisor).

Promotor: Prof. dr. A.G.G.M. Tielens

The corona crisis is also a disinformation crisis for the global community in general, and for the European Union (EU) in particular. What is less clear is how adequate the EU’s response to the ‘infodemic’ has been. This essay exposes the dangers of disinformation for the EU, which have intensified…