Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Conference

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Was the progressive colonial civil servant the precursor of the postcolonial development-aid worker?

Set up in 1991, this unique project aims to identify and describe the common lexical heritage of the most important Indo-European languages and language branches. The project has thus far resulted in twelve volumes published as The Leiden Indo-European Etymological Dictionary Series (Brill, Leiden).

Political Islam is not new to the Middle East, but the appearance of ISIS has stretched the phenomenon to the extreme.

The book Uitdagend gedifferentieerd vakonderwijs bij Janssen, Hulshof and Van Veen describes a 'generative toolkit' for adapting education by teachers.

When the 'New World' was really new, the Frankfurt publisher and engraver Theodore de Bry drew inspiration from some of history’s greatest explorers to record its wonders.

In the field of Western art music, improvisation has become a much discussed topic. In this interdisciplinary study I argue that in this context, improvisation is not to be seen as a quasi-autonomous skill or art form, but as an aspect of music-making in general.

How do lecturer-researchers at Dutch Universities of Applied Sciences perceive their academic identity after expanding their teaching-only work portfolios to include researcher roles, and how do they navigate attached identity-based role transitions, while balancing personal goals, institutional expectations,…

The Business Studies Seminar (BUSS) Series features invited scholars’ seminars on organizational, legal, and technological research. In 2024, the Organizational and Entrepreneurial Behavior, Technology and Innovation, and Corporate Governance and Strategy research groups will invite diverse speakers…

The interdisciplinary network Faith in Democracy (FID) studies the religious, sometimes even totalitarian, assumptions behind the concept of

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Due to the fact that the Frisian lands lacked major political centers in the Middle Ages and also because most of its monasteries suffered complete destruction in the second half of the 16th century, relatively few written documents concerning medieval Frisian history have survived. To analyze them…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

This volume examines how the history of the humanities might be written through the prism of scholarly personae, understood as time- and place-specific models of being a scholar.

Politically speaking, the Frisian coastal area constitutes a special case in late medieval Europe since it was not subject to an overlord as it withstood feudalization in the 13th century. Its many sub regions, which were dominated by elites of small noblemen and freeholders, long time succeeded in…

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Fighting for the faith, caring for the sick, and praying for the soul of their benefactors were the main tasks of the military orders, who since the time of the crusades were well represented in the Netherlands in the Middle Ages, including the Frisian lands. Especially the Hospitallers and the Teutonic…

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Historical geo data are gaining in importance. Provided that they are exactly geo referenced, they can be stored into a GIS and thus be combined with all kinds of maps (topographical, pedological, etc.) and datasets. This makes it possible to analyze historical developments in space and time on a detailed…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Plastics are an intrinsic part of our society. Annually, 400Mt of plastics are produced of which roughly 40% is discarded within a year.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?

Information about the association and the board.

The research group New Rural History (in Dutch: de Nieuwe PLAG) aims to stimulate the study of rural history in the Netherlands, particularly its political and cultural dimensions. It will develop a handbook to support researchers who want to work on Dutch rural history and will foster new research…

A true shower of awards for students from the Faculty of Science during the annual KHMW Young Talent Awards ceremony. On Monday, 25 November, no less than nine first-year students received a prize for the best academic results in their first year. In addition, there were graduation prizes for master’s…

Labour is back as a significant social and political force in Indonesia, as was shown in the recent 1 May trade union demonstrations in Jakarta. Over the past years major changes have taken place in Indonesian labour law, leading to new forms of judicial and political resolution of labour disputes.

Interest groups play an important role in democratic society.

Although official law generally conceives of personal injury victims as individual rights holders, the actual experience of physical injury and its consequences is relational. Indeed, many researchers in the global North as well as the global South have contended that the very concept of the Self should…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

This project develops a scientific method to extract clinically relevant new information from patient forum websites that discuss patient experiences concerning e.g. medication, nutrition, co-morbidities, genetic factors etc.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Since my master's thesis on the landed property of the Frisian monasteries in the Middle Ages I am highly interested in the do ut des-aspects of the relation between religious houses and the lay world. Key words here are: property, power, patronage and the role of religious institutions in the 'salvation…

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Hermeneutics and the Humanities: Dialogues with Hans-Georg Gadamer / Hermeneutik und die Geisteswissenschaften: Im Dialog mit Hans-Georg Gadamer

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.