Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

On the 6th of November, Virginia Beavon Ham successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Virginia on this achievement.

This book looks to existential thinkers for reasons to hope immortal life could be worth living. It injects new arguments and insights into the debate about the desirability of immortality, and tackles related issues such as boredom, personal identity, technological progress, and the meaning of life…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: Prof.dr. J. Kuiper

The research at the Living lab attracts a great deal of press attention. Please find below a small selection of the many news reports that have been published. Also take a look at the Zembla programme about the Living Lab.

This book explores how physicists, astronomers, chemists, and historians in the late nineteenth and early twentieth centuries employed ‘epistemic virtues’ such as accuracy, objectivity, and intellectual courage. In doing so, it takes the first step in providing an integrated history of the sciences…

On the 2nd of July, Axel Palmér successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Axel on this achievement!

Ambient sound is a standard term used by sound practitioners to denote the site-specific background sound component that provides a characteristic atmosphere and spatial information in a sound work.

The main aim of this dissertation was to provide insight into possible subtle forms of bias in youth socialization by various socializing agents in the Netherlands, and exploring new ways to document bias. Additionally, it addresses the importance of using sound statistical methods for calculating effect…

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Tools and Data of the department of Environmental Biology

This doctoral research project in design seeks to shed a light on legibility in the context of visually impaired beginning readers.

This 25th volume in the series 'Islam in Africa', edited by Annachiara Raia, is a pioneering collection of poetry by the outstanding Kenyan poet, intellectual and imam Ustadh Mahmmoud Mau (born 1952) from Lamu island, once an Indian Ocean hub, now on the edge of the nation state.

On 16 January 2020, Maaike Wensveen defended her thesis 'Eigen haard is goud waard?'. The doctoral research was supervised by Prof. P. Nieuwbeerta and Dr. J.M.H. Palmen.

Work placement as a professional development programme for vocational teachers has been widely implemented. This dissertation provides insight into vocational teachers’ learning process in this programme within Chinese vocational education.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

What is the role of emotion regulation in coping with interpersonal feedback?

Fundamental research in the ALgebra, Geometry And Number Theory

Leiden University was founded in 1575, thanks to William of Orange. According to tradition, he founded the University to reward the citizens of Leiden for their resistance to the Spanish occupiers.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Material culture and the role of rural communities in exchange systems of the eighth and ninth centuries

Matthias Haentjens, Jouke Tegelaar and Dorine Verheij have recently published the chapter Financial Market Regulation and Supervision in the new volume of the prestigious The Law of the European Union (previously Kapteyn and VerLoren van Themaat).

This article provides a list of the concepts and key elements that should be considered when creating effective communication messages.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

The project aims to explore Eurasian elk's role in the ecosystems of the past and its relationship with humans through analysis of its distribution and habitat in the Netherlands.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The authors in this volume explore how external innovations (products, technologies, services, institutions and processes) have been appropriated in African societies in order to be acceptable and relevant to local conditions, expectations and demands.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh

High resolution altitude data created by airborne LiDAR allow the investigation of large areas and often inaccessible tracts of land and has the potential to reveal undiscovered archaeological heritage.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Have you ever wondered how you can increase the visibility, accessibility, and recognition of your research while complying with funding and national requirements? LUCRIS is the answer!

Why do certain incidents of serious violence end lethally whereas others do not? What role do personal characteristics of offenders and victims play and how do immediate situational factors influence outcomes?

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

This dissertation is the first comprehensive description of Makalero, a language spoken by approximately 6,500 speakers in the Iliomar subdistrict, in the south-east of the Republic of East Timor. While previous sources considered it to be a dialect of the larger language Makasae, the present study,…

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Berichtigungsliste der Griechischen Papyrusurkunden aus Ägypten, Dreizehnter Band. Herausgegeben von F.A.J Hoogendijk und A. Jördens. Zusammengestellt von J.M.S. Cowey und F.A.J. Hoogendijk (Leiden-Boston, Brill, 2017).

On the 16th of February 2022 Mr. Yunus Sulistyono successfully defended a doctoral thesis and graduated.

On 17 April, Evert-Jan Govaers defended the thesis 'Ministers of State. Unknown and desired; from stage to the wings?'.The doctoral research was supervised by Wim Voermans.

The Ager Venusinus Project studies the relatively small number of recognized colonial dwellings dated securely to the period of colonization (i.e. the 3rd century BC). With a special interest in the Black Gloss ceramic typochronology

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

On 11 November 2021, Mariana Gkliati defended the thesis 'Systemic Accountability of the European Border and Coast Guard'. The doctoral research was supervised by Prof. P. Rodrigues and Prof. L. Besselink (UvA).

On the 12th of November, Xander Vertegaal successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Xander on this achievement!

The goal is to reduce single use coffee cup use both at the university cafés and cofee machines.

On the 28th of September, Jiang Wu successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Jiang on this achievement!

In Humanity’s End As A New Beginning, Emeritus Professor Mineke Schipper reflects on myths about ‘the end’.