Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Intergenerational transmission refers to the complex and dynamic process with which values, ideas and behaviors are transmitted across generations. We are specifically interested in the intergenerational transmission of behaviors and beliefs that might result in harm to the individuals involved or society…

Kantorowicz & Voigt examine whether federal systems, with their multiple levels of government, lead to higher constitutional compliance

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

We investigate emergent structures and dynamics of soft materials self-assembled from microscopic constituents.

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

What are the mechanisms involved in the reconciliation of value conflicts and which interventions are capable of resolving such disputes?

This book contextualizes the use of terror as part of wider movements of political contention, demonstrating that terroristic innovation occurs as part of wider historical processes rather than in a vacuum.

The project investigates how bilingual speakers navigate lexico-syntactic features, including grammatical gender, classifier systems, and the linear order of adjectives and nouns, across Spanish and Chinese in both unilingual and bilingual contexts.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

The production, use, and exchange of bodily ornaments through the lenses of the microscope

List of Support Departments at LION and the Faculty of Science

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Can international organisations be held responsible for violations of international law by peacekeepers in a peacekeeping operation?

Heart failure is a major health care problem with high mortality.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

How do mycobacteria subvert the defenses of host immune cells?

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Complaints against decisions not to prosecute in socially sensitive issues.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Can we link multiple components from herbal extracts with their biological activities?

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

What is the role of the noradrenergic system in human cognition?

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

This thesis investigated the extent to which participation of school students in decision-making processes can be achieved, including through participatory action research (PAR) in teacher education.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Does student and teacher gender affect students’ performance and what is the role of gender stereotypes in this relation?

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Marc Koper’s research focuses on electrocatalysis and electrochemical surface science for sustainable energy and chemistry. Reactions of interest are the redox reactions of the oxygen/hydrogen cycle (water oxidation, hydrogen evolution), the carbon cycle (reduction of carbon dioxide, oxidation of small…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

On the occasion of prof Paul van der Heijden’s stepping down as Rector Magnificus and President of the Executive Board of Leiden University in 2013 the Chair bearing his name on Social Justice was established. It was a “farewell present” of the Leiden University to it’s Rector.

This volume publishes the proceedings of the eleventh annual University of Chicago Oriental Institute Seminar. It uses the sphere of legal institutions as a prism through which to consider gender relations in the ancient world, both in the Near East and beyond. It examines how similar issues were manifested…

From basic science to real-world interventions