This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

This dissertation examines the airs sérieux contained within the Recueils d’airs serieux et a boire de differents autheurs published by the Ballard printing house in Paris between 1695 and 1699 inclusive.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This book analyses the emergence of modern parties in nineteenth-century Europe and explores their connection with the slowly developing institution of democracy.

In this study, Tessa Dool and Thijs Bosker estimate the microplastic uptake of two odontocetes in the Mediterranean Sea and the Norteast Atlantic.

Tom Buitelaar is an Assistant Professor in the War, Peace & Justice program of the Institute of Security and Global Affairs. This paper suggests a number of important avenues for states, the UN, and the ICC to improve the likelihood that the ICC receives assistance from UN peace operations.

The Europaeum is a network of 17 leading European universities, whose aim is to bring together talented students and teachers and to promote a 'European feeling' through cooperation and academic mobility.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Complaints against decisions not to prosecute in socially sensitive issues.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Surveying Indigenous Peoples’ culinary practices prior to the advent of European invasions in the Greater Caribbean

This thesis describes the design, characterization and application of dextran based crosslinked network.

Reconstructing interactions between communities in and out of Cyprus in the early third millenium BC

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

As our society becomes increasingly complex, it is critical that we better understand how we can deal with fundamental issues such as societal and personal security, and resilience against threats to our security.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Jaroslaw Kantorowicz and Rok Spruk examine the contribution of institutional reforms to economic growth.

On the 12th of May, Rita Barrera Virhuez-Eloranta successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Rita Barrera Virhuez-Eloranta on this achievement.

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Tom Buitelaar is an Assistant Professor in the War, Peace & Justice programme of the Institute of Security and Global Affairs. This paper discusses four important challenges to the involvement of UN peace operations in international criminal justice: its effects on host state relations, peace and justice…

The central goal of academic publishers is the dissemination of the results of research and scholarship. Their audiences can generally be divided into two categories. Academic publications are firstly made accessible to the scholarly community, so that these texts can form the input for new academic…

Research on lethal violence related to criminal activities.

People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

Recent studies of Neandertal body mass and skin surface indicate raised energetic requirements in this lineage compared to anatomically modern humans.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

The Global Transformations and Governance Challenges Programme hosts a range of international academic gatherings, including the GTGC Conference, the GIG-ARTS Conference in 2024, and the first edition of the Just Peace Festival in 2025.

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

On 18 November 2020, Mojan Samadi defended her thesis 'Normering en toezicht in de opsporing'. The doctoral research was supervised by Prof. J.H. Crijns.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The Mathematical Institute regularly has vacancies. These are advertised on the homepage of the Mathematical Institute or on the general website of Leiden University. You can also join the Mathematical Institute as a guest, and of course you can also pursue a bachelor's or master's degree with us.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The present study aims to establish and develop guidelines for effective use of the classical guitar’s scoring potential.