This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Up to 50% of individuals with Parkinson's disease develop cognitive impairment over time; this study explores the use of 'practice effects' on neuropsychological tests as an early predictor of cognitive decline.

Why are professors still warning their students against dogmatism, prejudice, pedantry, and other centuries-old vices? What explains the persistence of these scholarly vices across the ages?

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

The Board of Governors monitors the management and administration of the University as a whole, and assists and advises the Executive Board.

Leiden Law Practices (LLP)

Foute taal? Bestaat niet!

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Conference

The course is taught by experts from Leiden University’s Institute of Security and Global Affairs (ISGA) from Leiden University, and guest speakers from various countries and universities. They bring academic depth and practical experience from the fields of security policy, counterterrorism, and international…

Voor zowel archeologen, paleontologen en geologen als vrijwilligers in de archeologie en paleontologie is het geen verrassing meer dat op de stranden van de Nederlandse kust fraaie vondsten gedaan kunnen worden. Vele artikelen, boeken, tentoonstellingen, congressen, lezingen, ‘zoekdagen’, krantenberichten,…

Comparative and Dutch Politics is one of the three organisational clusters of the Institute of Political Science.

The question of how military interventions can best transition to a long term counter-terrorism policy forms the core research question of three interlinked reports. This research project has been completed with support of NATO’s Science for Peace and Security Programme. Leiden University researchers…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Employees are now in a better position to negotiate the terms and conditions of their employment. This is mainly visible in wage increases and fringe benefits. Olaf van Vliet, Professor of Economics at Leiden University, spoke to NU.nl about workers' improved negotiating position.

On Thursday 17 February 2022, a mid-term review was held for the Advanced LLM programmes Air and Space Law, European and International Business Law, International Civil and Commercial Law, Law and Digital Technologies, International Children’s Rights, European and International Human Rights Law, Public…

Since the attack of 22 may 2017 in the Manchester Arena, we have often seen the term ‘soft target’. Jeanine de Roy van Zuijdewijn, researcher at the Institute of Security and Global Affairs, took part in a Q&A about the attack in Manchester.

What practical knowledge do mentor teachers have of adaptive mentoring and of individual differences between student teachers?

Important note: upon careful consideration, we have decided to resume our Dutch language courses.

Key publications of the Quantitative Pharmacology group

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

De menselijke geschiedenis strekt zich ver uit vóór de tijd waarin de mensen opschreven wat er zoal gebeurde.

The Oxford Handbook of Dutch Politics provides a comprehensive longitudinal overview of the state of the art of academic research on the Dutch political system: its origins and historical development, its key institutions, main fault lines, pivotal processes, and key public policy dynamics. In each…

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Schatten uit het oude Armenië

Do objectively correct solutions to ethical dilemmas exist? Or is ethics always a matter of your opinion against my opinion? How do you know what to do? What kind of thing is ethics anyway? Can you be an expert in ethics?

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

The Covid-19 'infodemic' and conflict resolution by internet platforms.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Meet the scientists within the LED3 community

Marieke Liem wrote a contribution for DJIzien, a magazine published by the Dutch Custodial Institutions Agency (Ministry of Justice and Security), about her meetings with long-term prisoners. ‘For my research on long-term prisoners I made numerous visits to Dutch prisons. During these visits, I came…

After Zelensky and Putin, President Biden has also used the word ‘genocide’. We should not use the term genocide too loosely, says Professor of Public International Law Larissa van den Herik.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

Originating from a collaboration between Leiden University, the Leiden University Medical Center, and the Technical University of Munich in 2021, the Virtual ChemBioTalks are an annual, half-day virtual event with world-leading speakers from all sub-disciplines of Chemical Biology.

Victorian Fairy Tales

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

After a turbulent first year as assessor, Jonatan Wirix-Speetjens starts a second term in September: 'In my second year as assessor I hope to become really decisive’, says Jonatan. We asked him about his experiences the past year and his plans for the coming academic year

On 5 September 2019, Jennifer Doekhie defended her thesis 'Dimensions of desistance: A qualitative longitudinal analysis of different dimensions of the desistance process among long-term prisoners in the Netherlands'. The doctoral research was supervised by Prof. P. Nieuwbeerta.

Op vrijdag 16 februari wordt het boek "Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550)", geschreven door Andrea van Leerdam, bij de KB gepresenteerd. De presentatie is gratis en voor iedereen toegankelijk. Wel is het nodig om te…