10,000 search results for “Research” in the Public website
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After your PhD
PhD Candidates are encouraged to start thinking about job prospects well before the defence of their thesis. This page contains information about how to prepare yourself.
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Privacy and identity
What issues arise in the changing landscape of privacy, identity and data protection?
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Terpenoids and terpenoid indole alkaloids in Catharanthus roseus cell suspension cultures
Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Understanding the physical properties that affect the lipid organization in the skin barrier
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Active Learning Network
The active learning network joins together everyone interested in the subject to move the theme further within Leiden University. The SALTSWAT pilot program researches the ways forward for Leiden University.
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Managing our past into the future: Archaeological heritage management in the Dutch Caribbean
Caribbean archaeological heritage is threatened by natural impacts but also increasingly by economic developments, often resulting from the tourist industry. The continuous construction of specific projects for tourists, accompanied by illegal practices such as looting and sand mining, have major impacts…
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HomininSpace – a large scale simulation system for hominins in the past
HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…
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Tragedy in Ethics and Law: Other Voices of Dionysus
This book explores the relationship between tragedy and the justice that is sought in moral philosophy and the law. It shows how our moral and legal judgments can be seen as aesthetic or tragic judgments, and it considers what kind of passion or vocation moves the science and scholarship of law.
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Chemistry and characterization of the graphene basal plane and edge for recognition tunneling
Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.
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Multi-angle DLS Facility
Multi-Angle Dynamic Light Scattering (MADLS) is a technique that is used to determine properties of particles in suspension. The measurements give the hydrodynamic size distribution of individual particles as well as particle clusters, and assists in the interpretation of the stability of the particles…
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Training future crisis communication advisers in crisis response: Applying scenario-based learning
In this article Wouter Jong and Andrea Bartolucci explore the integration of scenario-based learning (SBL) into a crisis communication course to enhance students' practical skills and reflection in real-world contexts.
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Combining Participatory Mapping and Geospatial Analysis Techniques to Assess Wildfire Risk in Rural North Vietnam
Andrea Bartolucci is Assistant Professor at Institute of Security and Global Affairs. In this study, the scholars adopted a multidisciplinary approach to investigate wildfire risk in Van Chan district in northern Vietnam, a region where official data are sometimes difficult to collect or inconsisten…
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Law and Artificial Intelligence, Regulating AI and Applying AI in Legal Practice
From deepfakes and disinformation to killer robots, surgical robots and AI lawmaking: AI (Artificial Intelligence) is changing our world. That raises the question whether this requires some form of regulation. At eLaw, the Center for Law and Digital Technologies at Leiden University, prof. Bart Custers…
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Essays on trends in income distribution and redistribution in affluent countries and China
Over the last decades, income inequality has increased globally. How do social policies affect this increasing trend? How do international trade and technological progress affect inequality? What is the profile of income inequality in China?
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Robert Zwijnenberg: what makes us human?
Advanced biotechnology allows us to select or alter the genetic makeup of human embryos. What limits do we impose on biotechnological intervention in nature and the human body? And whose call is that?
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Fertility and fontanels: women’s knowledge of medicinal plants for reproductive health and childcare in western Africa
Promotor: Prof.dr. E.F. Smets, Co-promotor: T.R. van Andel
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Science teachers' knowledge development in the context of educational innovation
The research reported in this thesis is concerned with the knowledge development of a small sample of experienced science teachers in the context of a broad innovation in Dutch secondary education, including the introduction of a new syllabus on Public Understanding of Science.
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Green Paper
What role should the university play in the climate crisis?
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.
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How Bio-questionable are the Different Recombinant Human Erythropoietin Copy Products in Thailand?
The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.
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How Terror Evolves: The Emergence and Spread of Terrorist Techniques
This book contextualizes the use of terror as part of wider movements of political contention, demonstrating that terroristic innovation occurs as part of wider historical processes rather than in a vacuum.
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Machine Learning in Quantum Sciences
Cambridge University Press has published a new book co-authored by researchers from Leiden University, offering both an introduction to machine learning and deep neural networks, and an overview of their applications in quantum physics and chemistry — from reinforcement learning for controlling quantum…
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Leiden Journal of Pottery Studies 20
Leiden Journal of Pottery Studies 20, 2004
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Computational linguistics
Computational linguistics uses computational methods to help answer linguistics questions across a variety of topics.
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Arabic and its Alternatives
Arabic and its Alternatives discusses the complicated relationships between language, religion and communal identities in the Middle East in the period following the First World War.
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Anthropology of Law in Muslim Sudan: Land, Courts and the Plurality of Practices
Anthropology of Law in Muslim Sudan analyses the hybridity of law systems and the plurality of legal practices in rural and urban contexts of contemporary Sudan, shedding light on the complex relation between Islam and society.
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The Rise and Decline of an Iberian Bourgeoisie
The Rise and Decline of an Iberian Bourgeoisie is one of the first long-term studies in English of an Iberian town during the late medieval crisis. Focusing on the Catalonian city of Manresa, Jeff Fynn-Paul expertly integrates Iberian historiography with European narratives to place the city's social,…
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The Mechanical Sky
In what ways can a photographic practice act as a means to confront, or even undo, the various material properties of atmospheric enclosure that so clearly put our relationship with our environment under pressure? Is it possible to devise a set of critical and artistic strategies to comprehend the ways…
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Embodied Imamate: Mapping the Development of the Early Shiʿi Community 700-900 CE (ImBod)
Imami Shiʿism was a key part of the turbulent thesis and antithesis which formed Islam, and it remains greatly influential today. The aim of the ImBod project is to write the first comprehensive social history of the Imamate.
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Understanding continuity and change in US counterterrorism policy through policymaker profiles
Has there been continuity or change in US counterterrorism policy since 9/11? What factors led to the continuity or change, and how do we classify any such continuity or change?
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Bottlenecks and opportunities for improvement in cybercrime handling: Insights from Dutch police practice
The authors examine the handling of cybercrime cases by law enforcement officers, focusing on bottlenecks and potential improvements noted by experts in the field.
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Met de voeten in het water
Publication on the excavations at Roman fort Matilo in Leiden
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Indigenous adornment in the circum-Caribbean
The production, use, and exchange of bodily ornaments through the lenses of the microscope
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
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Creating Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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For whom?
Leiden University's Pre-University College is for secondary school pupils that are looking for an extra challenge and are curious about science. Prerequisite is that your school is a partner of the Pre-University College.
