The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Promotor: Prof.dr. J. Kuiper

Plastics have become an integral part of modern society due to their versatility and durability.

This book explores how physicists, astronomers, chemists, and historians in the late nineteenth and early twentieth centuries employed ‘epistemic virtues’ such as accuracy, objectivity, and intellectual courage. In doing so, it takes the first step in providing an integrated history of the sciences…

On the 2nd of July, Axel Palmér successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Axel on this achievement!

The Iberian Peninsula has been central to the discussion as it was considered to be a 'last refuge' for the species at a time when H. sapiens occupation spread throughout Europe. Much speculation has centred around the idea that extreme climate fluctuations during Marine Isotope Stage (MIS) 3 like Heinrich…

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

The aim of this research is to investigate the informative potential of drawings and decorations in Italian secular cantata manuscripts from the seventeenth century.

The main aim of this dissertation was to provide insight into possible subtle forms of bias in youth socialization by various socializing agents in the Netherlands, and exploring new ways to document bias. Additionally, it addresses the importance of using sound statistical methods for calculating effect…

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

A teacher perspective

What legislative and regulatory questions arise when children, adolescents or elderly people use the Internet?

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

On 16 January 2020, Maaike Wensveen defended her thesis 'Eigen haard is goud waard?'. The doctoral research was supervised by Prof. P. Nieuwbeerta and Dr. J.M.H. Palmen.

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Human impact and plant subsistence in Dutch wetlands during the Late Mesolithic and Early and Middle Neolithic (5500-3400 cal BC)

On 9 April 2020, Mohamed Azizi defended his thesis 'Reflecties op Wereldburgerschap: In de spiegel van Afghanistan en Nederland'. The doctoral research was supervised by Prof. P.B. Cliteur en Prof. W. Veugelers (Universiteit voor Humanistiek).

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

This book explores the relationship between the production of new urban spaces and illiberal community-making in contemporary India. It is based on an ethnographic study in Noida, a city at the eastern fringe of the state of Uttar Pradesh, bordering national capital Delhi.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Here you can find products and research tools developed by the Navigation Lab Leiden

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

In his historical analysis of upland societies of the Zomia massif, James Scott (2009) emphasizes how the modern state strives to control and “make taxable” all of its subjects. For Tania Murray Li (2014), the development of neoliberal markets is the primary driver of change, as she shows based on long-term…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

On Wednesday 23 October 2024 Judith Jurjens successfully defended a doctoral thesis and graduated.

At Leiden University there are currently three different locations where there are AI Facilities in the form of laboratories: - The Digital Lab part of the Humanities Hub in the Huizinga Building - The Physical Twin Lab in the Gorlaeus Building - The Archaeology Lab in the Van Steenis Building

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

The curators and conservator share fascinating stories about physical objects from the Special Collections through regular blog posts.

The role of the interfacial environment during electrochemical reactions has been increasingly valued, especially for those reactions involving protons or hydroxyl ions.

Part of ‘Moralising Misfortune: A Comparative Anthropology of Commercial Insurance’, an ERC Consolidator project of Erik Bähre.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Just as in phase 1, phase 2 of the Gorlaeus Building will focus on sustainable building.

The project aims to explore Eurasian elk's role in the ecosystems of the past and its relationship with humans through analysis of its distribution and habitat in the Netherlands.

The Dutch child protection system

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

A thorough description of the relationships among languages and their social environment in a given context, reflecting an ecological perspective, involves attention to the agency of local actors, and the policies, discourse, and ideologies that surround them.

Changing the world (a little bit)