This book explores how demographic changes, especially population decline and ageing, influence digital innovation within the public sector. Drawing on an analysis of 110 Italian municipalities, the research illuminates the under-researched impact of 'big but slow moving' macro-level factors.

From Soledad Acosta de Samper and Albalucía Angel to Hazel Robinson Abrahams and Amalialú Posso Figueroa. During the Symposium & Workshop Experience and Voice: Library of Colombian Women Writers, Carolina Olarte-Bácares, Ambassador of Colombia, donates the Biblioteca de Escritoras Colombianas to the…

Phonology is the study of speech sounds within and across languages. It touches topics such as speech sound variation, speech sound combinations and acquisition.

This comparative study investigates court politics in four kingdoms that succeeded the south Indian Vijayanagara empire during the sixteenth to eighteenth centuries: Ikkeri, Tanjavur, Madurai, and Ramnad. Building on a unique combination of unexplored Indian texts and Dutch archival records, this research…

In this article, Annemiek de Looze and Eefje Cuppen, investigated empericallly if and how social conflict leads to institutional change.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

The Institute of Education and Child Studies is located in the Faculty of Social and Behavioural Sciences of Leiden University near Central Station.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Computer applications and quantitative methods in archaeology CAA95.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

The Future of Multilateralism addresses current challenges and future perspectives of international and regional organizations. It aims to uncover how stable the foundations of global cooperation really are, particularly in the light of the latest unilateral and protectionist practices of international…

Bringing together scholars from a broad range of theoretical perspectives, The Language of Argumentation offers a unique overview of research at the crossroads of linguistics and theories of argumentation.

Promotor: Huub de Groot, Co-promotor: Francesco Buda

Governments are increasingly facilitating the roll-out of so-called “smart meters”, a technology for measuring energy consumption that are able to transmit and receive data using a form of electronic communication. However, implementation has been slow or even stalled.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

The University Council is the central co-participation body of the University.

The MicroSOS project is designed to bring together academic and industrial partners with different expertises to address challenges that agriculture is facing due to climate change and invests in the development of microbiome-based solutions towards more sustainable agricultural practices.

University Lecturer Ahab Bdaiwi:

National and international actors have attempted to provide accountability for the events at Srebrenica in July 1995. This research project aims to draw lessons learned from those multiple efforts in assessing whether securing a measure of ‘justice’ for the victims has been successful and how national…

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Young Academy Leiden has conducted a survey among young academics of Leiden University.

The Early Upper Palaeolithic (EUP) record throughout Europe is characterized by major changes in human behaviour.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

The Faculty of Science is housed in various buildings situated in the Bio Science Park Leiden.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Our department aims to educate academic professionals who are prepared for the future of law and organization.

This thesis introduces the concept of

The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.

Reinforcement learning is a framework that enables agents to learn in a manner similar to humans, i.e. through trial and error. Ideally, we would like to train a generalist agent capable of performing multiple tasks and achieving various goals.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

This dissertation assesses the influence of British Celtic on the phonological development of English during and shortly after the Anglo-Saxon settlement period, ca. AD 450-700.

What are the humanities? As the cluster of disciplines historically grouped together as “humanities” has grown and diversified to include media studies and digital studies alongside philosophy, art history and musicology to name a few, the need to clearly define the field is pertinent.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

The Corfu Papers

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Nobody is better qualified to tell you what it is like to work at Leiden University than the employees themselves. Watch the videos and meet your future colleagues. They will be happy to share their experiences with you.

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

This research note argues that the “lone wolf” typology should be fundamentally reconsidered.

We are dedicated to creating a thriving open knowledge community. This challenges us to innovate and take action. Therefore, Leiden University commits to:

The Latin language is a descendant of the widespread Indo-European family of languages. Recent ancient genetic studies have helped shed light on the likelihood that the Indo-European languages spread into a Europe that had already been populated by farmers for thousands of years.

How do educational philosophies, discourses and practices spread around the globe, and how are they transformed and adapted locally?

What are the social, cultural, and/or educational consequences and challenges linked to the introduction of the international bachelor's programme in Cultural Anthropology and Development Sociology?

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Neo-Baroque construction and deconstruction of the concepts of paradise in fiction.