Knowledge and culture subproject 1:

Emeritus professors Dirk van Delft and Frits Berends both channelled their inner Sherlock Holmes as they delved into the life and work of the great physicist Hendrik Lorentz. Their voluminous biography ‘Lorentz: gevierd fysicus, geboren verzoener’ (Lorentz: celebrated physicist, born mediator) is published…

From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, explore our standout discoveries and most inspiring collaborations from the past year!

Tonal bilinguals of two closely related Chinese dialects are amazing people. They handle two tonal systems in their mind; their two vocabularies are from closely related dialects, and they write translation equivalents with common Chinese characters. Their unique language situation makes their mind…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Formulation of biopharmaceuticals

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

How to explain the apparent high success rates of the EU infringement procedures, which are the major tools for enforcing EU law, against the member states?

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Lecture, SMILE Talks

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

As an alternative to the diving board shaped force sensor, we are now developing a magnetically levitated small superconducting particle – or ‘Lead Zeppelin'' – as our mechanical resonator. We explore routes towards detection of gravity between small objects.

COI@Leiden organises activities and events throughout the year. These include a monthly seminar series on topics relating to conflict resolution and PhD labs to assist COI students in developing their research skills.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Beyond Empires explores the complexity of empire building from the point of view of self-organized networks, rather than from the point of view of the central state.

Climate finance, especially for developing countries, is crucial for limiting global warming to 1.5C. However, the current level of North -South climate finance is chronically inadequate. As the climate crisis intensifies, more actors are entering the climate finance market, transforming the global…

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Psycho-physiological studies for health and disease.

In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.

Labbe

The Future of Multilateralism addresses current challenges and future perspectives of international and regional organizations. It aims to uncover how stable the foundations of global cooperation really are, particularly in the light of the latest unilateral and protectionist practices of international…

Promotor: Prof.dr. M. Ubbink

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

The Resilience Center Leiden investigates how stress impacts the mental health of young people. For that, the team studies a multitude of factors, such as childhood experiences, the social environment, psychological factors, and neurobiological factors. With this multidimensional approach, we aim to…

Yuxi Nie defended her thesis on 15 October 2019.

The Clinical Psychology Educational Programme aims to provide specialized knowledge of psychopathology, diagnostic and treatment skills and related scientific research.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

The programme group Educational Sciences is one of the six programme groups within the Institute of Child and Education Studies at Leiden University.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The corona crisis is also a disinformation crisis for the global community in general, and for the European Union (EU) in particular. What is less clear is how adequate the EU’s response to the ‘infodemic’ has been. This essay exposes the dangers of disinformation for the EU, which have intensified…

We use laboratory animals to address research questions, but only when there is no alternative and the question cannot be answered in any other way. Read here why we conduct animals experiments.

National and international actors have attempted to provide accountability for the events at Srebrenica in July 1995. This research project aims to draw lessons learned from those multiple efforts in assessing whether securing a measure of ‘justice’ for the victims has been successful and how national…

Promotor: J.M. Memelink

Violence during war often involves upswings and downturns that have, to date, been insufficiently explained. Why does violence at a particular point in time increase in intensity and why do actors in war decrease the level of violence at other points? Duyvesteyn discusses the potential explanatory variables…

Check back regularly on this page for research opportunities of interest to Humanities staff and students employing digital tools and methodology.

In this paper, Kantorowicz aims to track the persistent effect of former partitioning borders on property tax rates in Poland.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

During the period 500–1000 CE Egypt was successively part of the Byzantine, Persian and Islamic empires. All kinds of events, developments and processes occurred that would greatly affect its history and that of the eastern Mediterranean in general. This is the first volume to map Egypt's position in…

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…