Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Can Cyanobacteria be engineered to convert the greenhouse gas carbon dioxide into the valuable chemical isoprene?

Leiden University offers you several services related to career orientation and job application skills.

Leiden University offers you several services related to career orientation and job application skills.

Leiden University offers you several services related to career orientation and job application skills.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Leiden University offers you several services related to career orientation and job application skills.

Leiden University offers you several services related to career orientation and job application skills.

This PhD project investigates how automatic sign language recognition technology can be further developed to analyse static images and textual descriptions of signs.

An overview of our infrastructure at the SPP division:

Are you interested in combining your Science master programme with the Education specialisation? Learn more and watch the introduction video.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Leiden University was founded in 1575 and is one of the leading international research universities in Europe.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

How do processes of coalition-formation influence patterns of decision-making in the European Union?

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

How we think about and act on the usefulness of scientific research has epistemological and political implications: what knowledge consists of, how it comes about and to what ends. In this dissertation, I situate the usefulness of scientific research in concrete places for knowledge exchange. The exchange…

With the long lockdown, it’s been a hard year for Leiden businesses. How can the local economy bounce back and how can the University help? Two talk shows discussing this were recently recorded in the Academy Building. They will be aired on Unity TV on 28 September and 12 October.

The Leiden wall formulae, Einstein's sink or the signature wall of Ehrenfest. It are just a few of Leiden's hidden science treasures. Alumnus from the Leiden Observatory Alex Pietrow described a few of these places on travel website Atlas Obscura.

From monitoring pollution to tracking rainfall, citizen science comes in different shapes and sizes. But at its heart, it’s about the relationships between citizens, policymakers and researchers.

Investigating the intercultural connections that shaped practices of knowledge production in colonial Dutch Brazil.

Elephant toothpaste, a trip among the stars or a lecture on mathematical juggling: on Sunday 8 October 2023, the Faculty of Science opened its doors for the third edition of the Leiden Science Family Day. A programme jam-packed with workshops, demonstrations, lectures and peeks behind the scenes for…

As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…

Each year, Latin American diplomats meet the researchers and students from Leiden University who specialise in their region. This year, they visited the Faculty of Social and Behavioural Sciences. ‘The social and behavioural sciences have improved our understanding of social unrest.’

On 11 January 2022, the Faculty of Social and Behavioural Sciences opened the new year during a livestreamed reception. Dean Paul Wouters and Executive Director of Studies Kristiaan van der Heijden were the hosts. After several faculty prizes were awarded, our Dean expressed a new year’s resolution…

Scientists and non-scientists co-creating breakthrough citizen science projects for measuring, understanding, and mitigating air pollution. That’s what happened during the first international workshop of the newly established Citizen Science Lab from 22 until 26 January at the Lorentz Center at Leiden…

By delivering his inaugural lecture titled ‘Where Science Meets Business,’ Simcha Jong accepted his appointment as Leiden’s first Professor of Science Based Business. In his lecture in the Large Auditorium of the Academy Building, Simcha argued that broad universities with a focus on fundamental research,…

A festival that combines music and science, and a digital 'time machine' for science history: four Leiden projects that focus on science communication have been awarded a subsidy in the context of the National Science Agenda.