Professor Fons Verbeek of the computer science and biology institutes at Leiden University has the fascination to visualize everything we can not see immediately. At SleutelstadFM he tells us that by converting 2 dimensional (2D) images to 3 dimensional (3D) structures, research is carried out into…

A delegation from Leiden University will be visiting Mexico from 21 to 25 October. The visit aims to strengthen the ties between Mexican universities and Leiden University.

Tracking mucus-eating bacteria, mapping the complexity of planetary nebulae and a signalling pathway in cancer. These three Leiden projects have been awarded Open Competition Science-M funding by the Dutch Research Council.

With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…

Overkleeft

The challenge: Building a tool to detect chemical compounds that individually cause non-lethal stress to bacteria, but that are lethal in combination. A team of thirteen Leiden students are taking up this challenge in the annual ‘international Genetically Engineered Machine’ (iGEM) competition for applications…

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

Can Zebra finches learn to distinguish two very similar Dutch words? Research by behavioral biologist Verena Ohms proved that they can identify 'wit' and 'wet'. Ohms published her findings in

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

Professor Eline Slagboom has been studying multiple generations of families for over 20 years. She collects data on why some people age healthily and others decline early.

Lecture

PhD defence

Are you interested in taking up an extra challenge during your master’s programme?

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with University of California.

Supervisor: Natalia Ortiz Zacarías

Research at the SBC group is comprised of the following research themes:

Are you interested in taking up an extra challenge during your master’s programme?

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Annelot van Esbroeck-Weevers, PhD student at the Molecular Physiology research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt, has been awarded the Best Oral Communication Prize at the 8th European Workshop on Cannabinoid Research, held from 31 August to 2 September 2017…

Anthe Janssen, a PhD student in the Molecular Physiology research group of Prof. Mario van der Stelt, has been awarded the Public's Choice Prize for Best Oral Presentation during the Young Medicinal Chemist Symposium '18 in Ljubljana, Slovenia.

The rare Ethiopian wolf is increasingly coming into contact with local cattle farmers. PhD candidate Girma Eshete explored ways of saving this elegant animal from being wiped out. Phd-defense on 5 September.

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

Key publications of the Computational Drug Discovery group

Lecture

Scientific director Herman Spaink brought almost all scientific staff members of our institute together in Noordwijkerhout for a two-day meeting about strategies for the future.

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Promotor: Prof.dr. J.P. Abrahams

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Through courses and research projects, you are trained by experts in the field.