The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

Professor Eline Slagboom has been studying multiple generations of families for over 20 years. She collects data on why some people age healthily and others decline early.

The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.

Lecture

PhD defence

The rare Ethiopian wolf is increasingly coming into contact with local cattle farmers. PhD candidate Girma Eshete explored ways of saving this elegant animal from being wiped out. Phd-defense on 5 September.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Are you interested in taking up an extra challenge during your master’s programme?

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Supervisor: Natalia Ortiz Zacarías

Research at the SBC group is comprised of the following research themes:

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with University of California.

Are you interested in taking up an extra challenge during your master’s programme?

Annelot van Esbroeck-Weevers, PhD student at the Molecular Physiology research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt, has been awarded the Best Oral Communication Prize at the 8th European Workshop on Cannabinoid Research, held from 31 August to 2 September 2017…

Anthe Janssen, a PhD student in the Molecular Physiology research group of Prof. Mario van der Stelt, has been awarded the Public's Choice Prize for Best Oral Presentation during the Young Medicinal Chemist Symposium '18 in Ljubljana, Slovenia.

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

Key publications of the Computational Drug Discovery group

Lecture

Scientific director Herman Spaink brought almost all scientific staff members of our institute together in Noordwijkerhout for a two-day meeting about strategies for the future.

'Frans Rodenburg is an excellent teacher who is able to convey difficult information,' say his students. In his statistics classes, he wants to make students enthusiastic for his beloved subject. 'Most students are convinced that statistics is not for them. I am here to convince them otherwise.' Rodenburg…

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

Asexual procreation in female wasps leads to an accumulation of genetic mutations, and the shrivelling of their sex organ. Leiden biologist Ken Kraaijeveld published this discovery in Evolution. His research is one of the first experimental studies into the consequences of asexual procreation.

China’s booming aquaculture industry is increasingly dependent on fishmeal made from wild-caught fish, a practice that depletes wild fish stocks. A new study conducted by institutions including Leiden University and Stanford offers a more sustainable path. The study appeared in the journal Science on…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Promotor: Prof.dr. J.P. Abrahams

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Through courses and research projects, you are trained by experts in the field.

One of the main research focuses of the Hortus botanicus Leiden is to study how the current biodiversity we see today, has originated, changed, and developed over time. The Hortus wants to study the relationship between species in specific focal taxa and see how they have diverged over time.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotor: Prof.dr. M. Ubbink

Nonadiabatic energy transfer from the translational motion (T) of a molecule impinging on metal surface to the metal’s electrons may determine whether the molecule can lose enough energy to adsorb or react.

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…