The Leiden Institute of History approaches early modern and modern European history from comparative and transnational perspectives.

What are the environmental impacts of widespread integration of bio-based products into the construction industry?

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

Find out how to apply for Research in Bio-Pharmaceutical Sciences at Leiden University by following our step-by-step guide.

The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding mono- and multidisciplinary teaching.

In this conversation-analytic study, the authors analyze conversations between researchers from different disciplines and community members to examine relationship building in real life. This is an open access article under the Creative Commons By license.

Nature and History, Towards a Hermeneutic Philospohy of Historiography of Science

The Hortus botanicus Leiden has one of Europe’s largest collections of living plants from the Asian region. This rich resource is no longer the sole domain of botanists. Extraordinary professor Paul Kessler studies what the Hortus botanicus Leiden can offer research, higher education and the public…

Visualising structures of life

Science communication is a lot more than writing a column or giving a lecture now and then. The communication itself also has to be firmly based in sound scientific research, is the message of Professor Ionica Smeets in her inaugural lecture.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Route descriptions to CML by public transport or car

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Connect theory and practice of teaching through the application of your academic knowledge about chemistry to issues of classroom practice.

The Graduate School of Science offers PhD programmes spanning the entire spectrum of science from Mathematics to Environmental Science.

Cell adhesion signaling

Overkleeft

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

From bedtime stories about mathematics to podcasts about microplastics and games on weeds: master students from the Science Communication & Society track presented the real-life products they developed during their final presentations on 20 December. Many of the products are already implemented by c…

PhD students at Bio-organic Synthesis are invited to present their work during the weekly Monday Morning Biosyn Talks.

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

Fifteen knowledge institutions and the Ministry of Education, Culture and Science have signed the covenant for Open Science NL. Leiden University has also joined the covenant, via the Universities of the Netherlands. This marks the start of the Dutch Research Council’s and brings the transition to open…

A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.

In which way and to which extent is integration articulated in concept maps and which factors affect the resulting concept maps? By which factors is the perceived usefulness of such concept maps affected?

The RISIS project aims at creating a distributed research infrastructure to support and advance science and innovation studies. This will give the field a strong scientific push forward, and at the same time, provide a radically improved evidence base for research and innovation policies, for research…

Although the world has made tremendous progress in health, education, sanitation and hygiene, global public health challenges still exist. Disparities in health exist between and within nations as evidenced by inequalities in disease burden, mortality, nutrition and environmental well-being. How does…

The title of European City of Science was officially handed over to a delegation from Leiden in the Italian city of Trieste on 6 September. Leiden will be the science capital of Europe for the year 2022. The EuroScience Open Forum (ESOF), the largest interdisciplinary science conference in Europe, will…

BSc degrees: ‘Political Science’, ‘International Relations and Organisations’. MSc degree: Political Science, with specialisations ‘International Organisation’; ‘Dutch Politics; ‘Nationalism, Ethnic Conflict, and Development’; ‘International Politics’; ‘Political Legitimacy and Justice’; ‘Democracy…

Today, globalization makes us all aware of how closely we are connected to, and often dependent upon, the actions of people who are distant from us. Human migration and economic liberalization have confronted local communities with changes happening on a global level. How can we devise ways to share…

The Institute of Criminal Law and Criminology conducts extensive research on imprisonment. Sending a person to prison is the most severe form of punishment that can be applied in the criminal justice systems of European countries. In most countries, the number of prisoners has risen in recent decades.…