An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Medical Delta has appointed seven professors who will bridge the medical worlds of Leiden, Delft and Rotterdam.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Hass

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.

Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

The Institute Board is responsible for the overall management of the institute, as well as the administration and organization of the institute’s teaching and research activities. Research and education are managed collaboratively, with strategic input from various representatives and groups, including…

Songbirds apparently use mnemonics rather than more complex grammatical rules to recognise structures in which they have been trained. Leiden behavioural biologist Caroline van Heijningen published an article on this subject on Tuesday 17 November in PNAS.

Source: PLoS ONE, Volume 10, Issue 3 (2015)

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

In the Catalysis and Surface Chemistry group, we investigate how catalysis works on the molecular level. The group is divided in six subgroups, focusing on different aspects of heterogeneous catalysis, homogeneous catalysis and electrocatalysis.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

The

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

The Ig Nobel prize is awarded annually to ten studies that first

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

The Metabolomics Facility of the University of Leiden has brought together two research groups from the Faculty of Science that are well-known for their expertise in two different fields: the Biomedical Metabolomics Facility Leiden, experts in clinical metabolomics and the Natural Products Laboratory,…

Conact the Cellular Chemistry group

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Your time at Leiden is about more than just studying. Some of your best experiences will stem from being a part of our lively and diverse student community, as well as from life in the beautiful city of Leiden.

We are committed to provide you a meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors

Research at the BIOSYN group is comprised of the following research themes:

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The IBL Education Office consists of:

The new book of Professor of Character evolution and biodiversity Menno Schilthuizen gained a lot of media attention. ‘Darwin comes to town – how the urban jungles drives evolution’ was published in English in February and will be available in Dutch soon.

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Professor Fons Verbeek of the computer science and biology institutes at Leiden University has the fascination to visualize everything we can not see immediately. At SleutelstadFM he tells us that by converting 2 dimensional (2D) images to 3 dimensional (3D) structures, research is carried out into…

Lecture

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

Coordination chemistry is the chemistry of metal atoms