The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

Can photography embody the emotional and interpersonal aspects of home as well as participate in the social, political, and cultural debates on homemaking?

With the rise of information and communication technologies, large amounts of data are being generated and stored in databases. In order to get a better grip on these large amounts of data, serious efforts are being made to discover patterns and relations in the data with the help of new techniques.…

TruLife applies lessons from the study of long-term urban traditions, exemplified by pre-Columbian Maya tropical cities, to present-day sustainable urban design.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Drawing on a broad array of sources, this project examines modern retrievals of Bacon’s idols, thereby testing Justus von Liebig’s intriguing observation, back in 1863, that Bacon’s name lived on mainly in mottos or stereotypical phrases. More importantly, it examines the rhetorical purposes served…

The goal of the Kenniswerkplaats Diversiteit is to answer research questions schools in the Hague have in collaboration with the schools. The aim is to offer all children the same opportunities to develop through education.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

This book provides a comparative analysis of the process of breach across ten different European jurisdictions by identifying and elaborating a number of key analytical themes through which the different systems can be compared and evaluated.

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

On 19 September 2023 Tabitha Speelman successfully defended a doctoral thesis and graduated.

Tell Sabi Abyad is a major Late Neolithic settlement mound in Northern Syria, belonging to the seventh and early sixth millennium bc. This book presents the results of large-scale fieldwork conducted at the site between 1994 and 1999, under the auspices of the Netherlands National Museum of Antiquities…

This book offers a linguistic anthropological analysis of multilingualism among the Matsigenka, Quechua, and Spanish languages on the coffee frontier of Southern Peru, set against the backdrop of economic transformation and deforestation in the world’s last great forest.

On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.

Turnaround Wing of INSOL Europe and Leiden Law School are working on the design of ‘guidelines for out-of-court turnaround professionals’. The project was approved by the Council of INSOL Europe at its 2014 conference in Istanbul and subsequently started in November 2014.

In the History of the Roman Emperors, what does Herodian’s method of composition consist of and how does it relate to his writing intention, particularly in terms of political and moral idea(l)s?

Assessing Learning in Higher Education addresses what is probably the most time-consuming part of the work of staff in higher education, and something to the complexity of which many of the recent developments in higher education have added. Getting assessment ‘right’– that is, designing and implementing…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

The main focus of this research project is to investigate why people in Eastern Arabia chose to reuse ancient tombs and how this can be linked to collective memory.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

On the 17th of June Rea Matsangou successfully defended a doctoral thesis and graduated.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

Promotores: A.H. Meijer, H.P. Spaink

How can formative assessment be used to promote teacher professional learning? This book contains various studies into professionalization approaches and courses in which formative assessment is used with a view to teacher learning.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

How did the Dutch Empire compare with other imperial enterprises? And how was it experienced by the indigenous peoples who became part of this colonial power?

Subproject of

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World history, connectivity and material culture, edited by Martin Pitts and Miguel John Versluys. From Cambridge University Press.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

The aim of the project is to unravel the genetic and contact relations between the indigenous languages of Mesoamerica (Mexico and western Central America) and the Middle Andes region (Ecuador, Peru, Bolivia), as part of a larger endeavor to understand the historical process of the peopling of the Americas…

Research into the wishes and (care) needs of older migrants

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

How can we ensure a more resilient and sustainable supply of Rare Earths in the EU in the future?

On 25 January 2024 H.J. Pak successfully defended a doctoral thesis and graduated.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

This research aims to investigate how different social forces interact with hydropolitics in the Eastern Nile Basin and what are the constraints of engagement.

This study explores the role of linguistic data in the reconstruction of Dolgan (pre)history by analyzing contact-induced changes and using them to infer information about the nature of the contact settings in which they occurred.

Is the current existing legal framework on compulsory and voluntary care - for vulnerable young adults (between the ages of 18 to 23) - in need of revision? And if so, what kind of amendments would be advisable?

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

In the late 19th and early 20th century, hundreds of thousands of Chinese labor migrants crossed the seas to the Dutch East Indies. On the tobacco plantations of northeastern Sumatra and in the tin mines of Bangka and Belitung, they endured long hours and harsh conditions. Their journeys formed part…

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Proceedings of the 25th International Congress of Roman Frontier Studies 1