Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotor: J. Zaanen

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

The Divide & Quantum (D&Q) project offers various solutions to harness the power of quantum computers in the near term, proposing entire pipelines, from theoretical research, via implementation to real-world case studies in a number of disciplines, to science communication with the broader society.…

Excavations at Geleen-Janskamerveld 1990/1991

How can party bans be justified? Which parties were banned in post-war Europe – and why? Do militant democracy instruments work? Is an international militant democracy concept in the making?

What did it mean to be enslaved in in the Indian Ocean world in the 18th and 19th centuries? Over the last decades, historians have mined French, British, Portuguese and Dutch records for quantitative data on the European slave trade. This project focuses on the experience of being a slave and seeks…

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

Over 1,200 children from junior schools in Leiden and The Hague were taught by a real professor on the university's anniversary.

The Faculty of Humanities’ accommodation needs to be modernised. The education and research buildings are seriously outdated and non-sustainable, which could ultimately compromise the quality of our education..

Promotores: Prof.dr. A.G.G.M. Tielens & Prof.dr. L. Kaper (UvA)

Promotor: Prof.dr. G.P. van Wezel

The RISIS project aims at creating a distributed research infrastructure to support and advance science and innovation studies. This will give the field a strong scientific push forward, and at the same time, provide a radically improved evidence base for research and innovation policies, for research…

This dissertation defends the existence of a type of movement that has so far been considered not to be possible, namely, movement of a bare head to a specifier position over arbitrarily long distances.

Indonesian translation of the book Recollecting Resonances from authors Bart Barendregt and Els Bogaerts.

In citizen science projects, citizens and scientists work together to develop new scientific knowledge.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Leiden Observatory provides a dynamic, international environment for work and study. Established in 1633, the institute has a very rich tradition. The famous Old Leiden Observatory is the oldest operating university observatory in the world. At Leiden Observatory we carry out world class research and…

Newly published: ‘Background to Beakers’; inquiries into regional cultural backgrounds of the Bell Beaker Complex. Harry Fokkens / Franco Nicolis (eds.).

In the last two decades, there have been heated public and scholarly debates in France, the United Kingdom, and the Netherlands on the violent end of empire. Nevertheless, the broader comparative investigations into colonial counterinsurgency tend to leave atrocities such as torture, execution, and…

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Over the last decades, income inequality has increased globally. How do social policies affect this increasing trend? How do international trade and technological progress affect inequality? What is the profile of income inequality in China?

In the Netherlands, levying tax on inheritances at death has been a fact of life for centuries. The presumed double taxation and its sad precursor are elements of the discussion about the levy of this inheritance tax, but so too are the possibilities to reduce the tax through ingenious legal constru…

Science and education can really flourish in an environment where everyone can be themselves and where there is room for different perspectives that bring people together from different ethnicities, genders, sexual orientations, health, religion, age and socio-economic background.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

The HARVEST project explores the dietary choices that our hominin ancestors and relatives made, by recovering information on what they consumed, and how factors like environmental variation, intrinsic biology, and development of food processing technologies could have influenced their decisions.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Promotor: Prof.dr. M.L. van Hecke

Four different astronomical societies are active in the Old Observatory. We are very proud of the commitment these associations show to organize activities.

What are the arrangements for your pension? What are you entitled to? Until what age do you have to continue working? And can you decide for yourself how your pension contribution is invested?

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

This doctoral research project in design seeks to shed a light on legibility in the context of visually impaired beginning readers.

Route descriptions to CML by public transport or car

What motivates people to provide help to, or seek help from other groups? And what are the psychological consequences of receiving help from another group?

This book reveals how one publishing firm's editorial strategy helped to legitimate European colonialism in the early modern era.

State fragility and conflict continue to be among the most enduring development challenges of the 21st century. The consequences of fragility and conflict on individuals, States and the international community are profound. At the individual level, an estimated 2 billion people or a quarter of the world's…

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

This dissertation is the first comprehensive description of Makalero, a language spoken by approximately 6,500 speakers in the Iliomar subdistrict, in the south-east of the Republic of East Timor. While previous sources considered it to be a dialect of the larger language Makasae, the present study,…

The Heritage and rights of indigenous peoples focuses on the living heritage of indigenous peoples and its safeguarding, connecting the past and the present in local communities.

Source: J Med Chem (2015)

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.