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1,793 search results for “molecular biology” in the Public website

• 
  Wouter Driever PhD candidate

  Faculty of Science

• 
  Ioana Belcin PhD candidate

  Faculty of Science

• 
  Shuangmeng Yang PhD candidate / contract

  Faculty of Science

• 
  Evangelos Machairas PhD candidate

  Faculty of Science

• 
  Miriam Van der Veer PhD candidate

  Faculty of Science

• 
  Asad Halimi PhD candidate

  Faculty of Science

• 
  Menno Valk PhD candidate

  Faculty of Science

• 
  Noëlle van Egmond Guest researcher

  Faculty of Science

• 
  Nicky Janssen PhD-candidate

  Faculty of Science

• 
  Jakob van de Wall
• 
  Stephan Hacker Assistant Professor

  Faculty of Science

• 
  Georgia Andriopoulou PhD candidate

  Faculty of Science

• 
  Emily Strange Assistant professor

  Faculty of Science

• 
  Martijne Kannekens PhD candidate

  Faculty of Science

• Mutation-Driven Modulation of GPCR Pharmacology: Insights from Adenosine and Serotonin Receptors Research output

  This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

• Semisynthetic glycopeptide antibiotics Research output

  Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

• Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces Research output

  Promotor: G.P. van Wezel

• Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans Research output

  Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

• The Ecology and Evolution of Microbial Warfare in Streptomyces Research output

  The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

• Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays Research output

  Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

• Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning Research output

  The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

• Identification and characterization of developmental genes in streptomyces Research output

  Promotor: Prof.dr. G.P. van Wezel

• 
  Marije Niemeijer Assistant professor

  Faculty of Science

• 
  Bas ter Braak Postdoc

  Faculty of Science

• 
  Peter Bouwman Assistant professor

  Faculty of Science

• Proactive personality has stronger wake-sleep rhythm News - 24 January 2019

  Proactive zebrafish appear to have a much stronger wake-sleep rhythm than reactive fish. In the most reactive fish, rhythmicity appears to be lacking completely. This is shown with research by Leiden biologists, published in December 2018 in the journal BMC Biology.

• Design and Synthesis of Click Lipids as Tools to Study Immune Cell Metabolism Research output

  This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

• Leiden researchers visualise the 'guardian of our genome’ News - 18 January 2022

  The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…

• Expertise Centre for Interdisciplinary Genome Research

  The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

• Lipid bilayers decorated with photosensitive ruthenium complexes Research output

  Promotor: E. Bouwman, Co-promotor: S. Bonnet

• Ice and Gas in Protostellar Clouds and Planet-forming Disks Research output

  This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

• Aquatic Pollution from Light and Anthropogenic Noise (AquaPLAN) Research project

  Management of Impacts on Biodiversity: What are the effects of light pollution from cities and bridges and noise pollution from passing vessels and nearby road traffic on migratory fish passage and spawning in rivers?

• 
  Han de Winde Professor

  Faculty of Science

• Development of highly accurate density functionals for H2 dissociation on transition metals Research output

  Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

• Histone-DNA assemblies in archaea. Shaping the genome on the edge of life Research output

  All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

• Exploring the metabolism and toxicity of amino sugars and 2-deoxyglucose in Streptomyces Research output

  Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

• The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus Research output

  Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

• Systems diagnosis in chronic disease: prediction and evaluation Research output

  Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

• Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology Research output

  The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

• Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama Research output

  In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

• Vidi Grant for Stefan Semrau: how does bioelectricity shape embryonic development? News - 28 June 2018

  Leiden biophysicist Stefan Semrau was granted an NWO Vidi earlier this month. He will use the grant to study the role of electricity in embryonic development and tissue regeneration.

• Neanderthals could tolerate smoke News - 24 November 2020

  The idea that modern humans displaced Neanderthals because they were better protected against toxic smoke components is now under fire. An earlier study that put forward this suggestion has now been refuted by genetic research by scientists from Leiden and Wageningen. This new research was published…

• Biology student Sander van Zon: ‘We can still learn so much more about lichens’ News - 6 January 2023

  Lichens enthusiast Sander van Zon was eager to use his knowledge for his internship. He wrote an excellent thesis on lichens’ biodiversity in the city, of which his first scientific publication will appear soon. With it, he is nominated for the Leiden Science Young Talent Award 2022.

• 
  Jitske van Welsen PhD candidate

  Faculty of Science

• 
  Marjolein Crooijmans PhD candidate

  Faculty of Science

• Education Leiden Institute of Chemistry (LIC)

  Education & outreach

• Breakthrough by Leiden researchers in Pompe disease News - 2 May 2016

  Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

• Glucocorticoids in zebrafish Research project

  A novel in vivo model system for studies on glucocorticoid resistance

• 
  Merijn de Bakker Education and research staff member

  Faculty of Science

• NMR studies of protein-small molecule and protein-peptide interactions Research output

  Promotor: M. Ubbink, Co-promotor: G. Siegal