In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…

Dr Madalina Busuioc has completed a study for the European Parliament titled

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

The Violence and Violence Prevention research group at Leiden University focuses on understanding and preventing violence in modern societies. The group offers two key educational programmes: the Minor Violence Studies and the Governance of Violence specialisation within the Master’s in Crisis and Security…

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

On the occasion of prof Paul van der Heijden’s stepping down as Rector Magnificus and President of the Executive Board of Leiden University in 2013 the Chair bearing his name on Social Justice was established. It was a “farewell present” of the Leiden University to it’s Rector.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Ruobin Han defended her thesis on 21 March 2017

From basic science to real-world interventions

The aim of the RAISE study is to investigate how resilient people respond to stress. Specifically, we will study how key biological systems (HPA-axis, immune system) interact with the brain and social environment in order to facilitate resilient functioning after childhood adversities.

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…

Promotor: G.R. de Snoo

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Intergenerational transmission refers to the complex and dynamic process with which values, ideas and behaviors are transmitted across generations. We are specifically interested in the intergenerational transmission of behaviors and beliefs that might result in harm to the individuals involved or society…

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Wout Broekema highlights how organisations not only learn from crises but also forget, losing crucial knowledge and practices over time.

This thesis investigated the extent to which participation of school students in decision-making processes can be achieved, including through participatory action research (PAR) in teacher education.

In this research we have studied how teaching graphing formulas by hand (i.e. sketching a graph of a formula) could promote grade 11- and 12-students’ symbol sense.

International public finance is essential for global collaboration on climate change. With the deepening climate crisis and stagnant public finances, it is essential to maximize the impacts of limited resources, especially in the developing world. To this end, new public climate organizations have emerged,…

In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…

PhD defence

In 2021 many of our students and staff won fantastic prizes and were awarded important research grants. This is our traditional review of these successes as the end of one year marks the beginning of another.

In Leiden, light particles march into Wolfgang Löffler’s experiments one by one. His research focuses on acquiring the fundamental knowledge needed to develop quantum computers and networks.

Julia Cramer is the winner of NWO's Minerva Prize for 2017. Cramer will receive the prize for her research in the field of quantum science and technology.

Leiden physicists and international colleagues from Geneva and Barcelona have confirmed the mechanism that makes magic-angle graphene superconducting. This is a key step in elucidating high-temperature superconductivity, a decades-old mystery central to physics, which may lead to technological break…

PhD defence

PhD defence

To improve our teaching and reward excellent teaching assistants, the institute offers a Teaching Assistant Prize to the best teaching assistant of the semester.

This header image was once elected Image of the Week by De Volkskrant and won second place in the LION Image Award. The research behind it is no less successful if we’re counting prizes. Last August, group leader Tjerk Oosterkamp was awarded an NWO Projectruimte grant, and now NWO-TTW grants him an…

Leiden physicist Milan Allan and his group have discovered an apparent paradox within a material that has zero electrical resistance. They measured trapped charges, while charges should in theory keep flowing in the absence of resistance. The discovery could provide a missing piece of one of the big…

Lecture

Lecture

Sharing scientific data, transferring money, or sending other sensitive information online: with cryptography, applications make sure your data does not fall into the wrong hands. Mathematician Thomas Attema (CWI/TNO/Leiden University) helps with this. For his PhD research, he developed a new technique…