Supervisor: Lizi Xia

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

Researchers at Leiden Observatory study the fundamental physics that creates structure in the Universe. These processes collect matter into galaxies and gas into stars. With the use of powerful telescopes and advanced calculations and computer simulations, Leiden astronomers seek to understand the origin,…

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

Supervisor: Gerard van Westen

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

Decision support tool for cell therapy commercialization and business development

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

When you apply for admission, you’ll be asked to submit several documents.

Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…

Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…

When you apply for admission, you’ll be asked to submit several documents.

Within the two-year Astronomy master’s programme, you can choose from seven specialisations, ranging from fundamental or applied astronomy research in cosmology, instrumentation or data science, to combinations of astronomy research with education, management or science communication.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Sebastian Geibel, Anjali Pandit, René Olsthoorn, Alia, and Steffen Brünle.

Whether a microbe is beneficial or harmful to a plant can now be predicted with high accuracy thanks to bacLIFE. This bioinformatic tool with an intuitive interface makes it much easier to unlock the secrets of bacterial genomes. A group of Leiden biologists presented it in Nature Communications.

Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…

Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…

She narrowly defied bureaucracy and spent days angling for cod. In the North Sea, marine biologist Inge van der Knaap discovered that noise significantly disturbs fish behaviour. ‘There is now a lot of attention for underwater noise.’

An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…

Of the 111 Spinoza Prizes that have been awarded since 1995, 28 have gone to researchers from Leiden University.

Researchers at the Faculty of Science work at the frontiers of knowledge every day, tackling today’s major societal challenges. Their work is recognised through grants, prizes and other awards. We highlight some of these achievements below.

Current antibiotics only address very few target proteins in bacteria to kill them. Researchers know that there are more possible target proteins to tackle the bacteria. The question is: which ones. Thanks to the NWO Vidi Grant, Assistant Professor Molecular Physiology Stephan Hacker and his team can…

The discovery in 2001 of the importance of microRNAs turned the world of molecular biology upside down. The small particles of RNA also attracted the attention of university lecturer Erno Vreugdenhil. Vreugdenhil: ‘Within five to ten years the first microRNA-directed medicines will come onto the mar…

Having a bachelor's, a master's and a PhD in Chemistry, Elena Sánchez López shifted to a more biological field of research for her postdoc. She completed all her studies at the University of Alcala, in Spain, before applying for a LEaDing fellowship at Leiden University, a Marie Sklodowska-Curie Cofund…

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

Designing innovative algorithms, thinking outside the box, and brainstorming over coffee with his colleagues — this is what physicist Stefano Polla enjoys most. His success shines through in his nomination for the C.J. Kok Jury Award 2024 for PhD thesis of the Year.

Four researchers from Leiden University will receive funding from arthritis foundation ReumaNederland over the next five years. This should facilitate long-term research into arthritis.

The Institute of Biology Leiden has a new visiting professor as of the first of May. Bioinformatician Marnix Medema holds the Van der Klaauw chair for a year and looks forward to scientific collaborations and to boost the bioinformatics education.

On 16 January student Lisa Bruil from the Institute of Biology Leiden was awarded the annual prize from the Stichting Prof. dr. K. Bakker-Fonds for her outstanding results as BSc-student.

At the New Year’s reception of the Faculty of Science on 6 January, it was announced that Annelien Zweemer, Leiden Academic Centre for Drug Research, has been awarded the ‘Discoverer of the Year 2014’ prize. Matteo Brogi, Leiden Observatory, wrote the best dissertation in 2014 and Dennis Claessen, Institute…

An international consortium of research groups is aiming to develop novel antibiotics against the tuberculosis bacteria and two other deadly bacteria. The European Union has awarded a total of 18 million euros to the RespiriTB and RespiriNTM projects. Researchers from the Leiden University Medical Centre…

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

To be eligible for Molecular Genetics and Biotechnology at Leiden University, you must meet the following admission requirements.

Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…

On this page you can find information about previous CCLS events.

Lecture

Lecture

The representation of women in science is improving, also at the Faculty of Science. On 8 March – International Women's Day – we highlight the work of female scientists from our faculty.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

Han de Winde will step down as a member of the faculty board of the Faculty of Science from 1 September 2018. De Winde had been vice–dean at the faculty since 2013. As director of education he was responsible for the bachelor's and master's programmes at the faculty.

Fleur Visser was awarded a Veni grant by the Netherlands Organisation for Scientific Research (NWO). She is one of seventeen promising young Leiden scientists, who get the opportunity to develop their own ideas over a period of three years. Veni-funding is part of NWO's Talent Scheme, concerning…