In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…

A group of biology students are working on a solution to the world’s plastics problem by getting bacteria to make biodegradable plastic.

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…

Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…

Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…

‘By cleverly combining new techniques for analysing DNA at the level of individual molecules, we can achieve real breakthroughs in research into conditions such as dementia,’ predicts Professor John van Noort. Together with four leading biophysics research groups, he has written a review article in…

The number of lions in Kenya is decreasing alarmingly, due partly to the encroaching cities and the development of the countryside. Together with local scientists and inhabitants, Leiden biologists are studying how this decline can be halted. ‘Lions are cleverer than we thought.’

Nathaniel Martin has been appointed professor in the field of Bioorganic Chemistry within the Faculty of Science at the Institute of Biology Leiden, starting from 1 March 2018. His research focuses on using new (bio)chemical approaches to combat infectious disease, as well as on developing new molecular…

Dutch researchers are joining forces to conduct research together with a series of societal partners to keep the biological clock healthy in our modern 24-hour society. The BioClock consortium will receive a research grant of no less than 9.7 million euros for this. It is one of the projects that receive…

Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.

The Faculty of Science forges new research collaborations with the Institut Teknologi Bandung in Indonesia in the fields of tropical diseases, e.g. tuberculosis and medical biotechnology.

Scientists have discovered that starlings and parrots can imitate the complex sounds of Star Wars droid R2-D2 remarkably well. Their study reveals how the structure of a bird’s vocal organ determines its vocal abilities – and how citizen science helps uncover it.

Primate and test specialist Jane Goodall paid a visit to the Hortus botanicus in Leiden on 21 May for a ‘meet & greet’. Goodall, a world-famous researcher and nature protectionist, was presented with an orchid named after her and used the occasion to draw attention to the issue of plant protection.…

Bacteria that fluoresce green, blue or red may play a role in combatting resistance against antibiotics. Under the motto of 'Say yes to stress', thirteen ambitious Leiden students are aiming to amass 9,000 euros to carry out their research project.

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars, which are called exo-planets. They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems.…

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…

Supervisor: Maarten Doornbos

How do plant defense genes get activated?

The Human Origins group at Leiden University studies the archaeology of hunter-gatherers, from the earliest stone tools in East Africa, more than three million years old, to the origin of sedentary societies towards the end of the last ice age.

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Which plant leaf characteristics are involved in thrips resistance in tomato?

Research at the MCBIM group is comprised of the following research themes:

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

Supervisor: Lizi Xia

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

Researchers at Leiden Observatory study the fundamental physics that creates structure in the Universe. These processes collect matter into galaxies and gas into stars. With the use of powerful telescopes and advanced calculations and computer simulations, Leiden astronomers seek to understand the origin,…

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

Supervisor: Gerard van Westen

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

Decision support tool for cell therapy commercialization and business development

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Within the two-year Astronomy master’s programme, you can choose from seven specialisations, ranging from fundamental or applied astronomy research in cosmology, instrumentation or data science, to combinations of astronomy research with education, management or science communication.