Evolutionary and ecological interactions affect species on genetic and phenotypic levels. This theme aims to understand these processes at multiple levels: from molecules to genomes to populations and to communities. Our research focuses on evolutionary responses to anthropogenic change, the role of…

Knowledge and culture subproject 1:

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The goal of pre-clinical development is to bridge the transition from lead compounds to clinical candidates by comprehensively characterizing safety, efficacy, and pharmacological properties. Once a lead compound demonstrates promising activity in disease models, it enters pre-clinical development where…

Martin van Hecke and Lennard Kwakernaak (Leiden university and AMOLF) develop a mechanical metamterial that can count to ten in their research.

Lecture

What is the Electronics Department?

What mechanisms shape faculty members' perspectives on their teaching role in research intensive universities?

The Leiden University Europe Hub approaches Europe from a broad and inclusive perspective.

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

The International Criminal Law programme prepares you for a successful career within a multidimensional field, in Europe or around the world.

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Samir Negash, PhD candidate at Leiden University and Olaf van Vliet, Professor by special appointment Comparative Welfare State Analysis at Leiden University wrote a paper regarding the topic of immigration and the conditionality of unemployment benefits in OECD countries.

The Green algae Chara as model system for intra and inter cellular transport processes.

While many healthcare professionals indicate that they frequently use placebo effects and their mechanisms, there is little formal training on how to deal with placebo and nocebo effects in clinical practice. This project aims to address this gap between scientific knowledge on placebo and nocebo effects…

This research paper was requested by the European Parliament's Committee on Civil Liberties, Justice and Home Affairs. It was published by the International Centre for Counter-Terrorism (ICCT) in The Hague. Leiden University is one of the participating institutes in this publication and our researcher…

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the track-specific courses, the elective courses, a research internship and a thesis.

This research cluster is a part of the Institute of Political Science’s research programme ‘Institutions, Decisions and Collective Behaviour’. Its members focus on the democratic role of citizens and the representative links between voters and politicians.

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

What is emotion in human and nonhuman animals? How do emotions get to expression and how do they impact on our interactions, our decisions to trust, distrust or cooperate? Why do we mimic and synchronise affective processes?

The scientists at Babylab Leiden ensure that important knowledge is gathered about how babies learn to understand the world around them. Meet our Babylab Team and get to know our researchers!

In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…

The Leiden Institute of Physics (LION) is the coordinating partner in the Qluster research project, which was awarded a 2,9 million euro FET Open grant by the European Union. The three-year project, which started on 1 December 2019, aims to produce many photon entanglement to aid quantum communication…

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Politicians' statements often involve emotions, shaping public perceptions. This study highlights the role of emotions in EU foreign policy.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

We study the physics of a broad range of biological and soft materials

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

This doctoral thesis elaborates Langacker’s reference-point model by applying it to lexical semantics.

Early Christian Encounters with Town and Countryside - Essays on the Urban and Rural Worlds of Early Christianity.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Four different astronomical societies are active in the Old Observatory. We are very proud of the commitment these associations show to organize activities.

When combined and used by specific people located in time and place, words can express something more than, different from, or even the opposite of their dictionary meanings.

Promotor: T. Schmidt

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On the 25th of September, Yufang Wang successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Yufang on this achievement!

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.