Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Master projects are available in

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

Promotor: A.P. IJzerman

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Do understudied animals contain hidden species?

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Source: Eur J Med Chem (2015)

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.

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Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…

Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.

Fourteen bachelor’s and master’s students are representing Leiden University in this year’s International Genetically Engineered Machine competition (iGEM). Their plan: to create a kit that can be used to quickly identify infectious diseases in case of an outbreak.

Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…

The construction of the new building for the Faculty of Science is in full progress. The Cell Observatory of the Institute of Biology Leiden will be moving to the new building in the beginning of 2016. Professor Annemarie Meijer and Dr. Marcel Schaaf had a sneak preview.

An international team from the Netherlands, France, Norway and Austria demonstrate how new sequencing technologies can be used to efficiently generate the genome, DNA, sequence of an endangered animal, the European Eel.

Is it a coincidence that three chemists from the same department have each independently received a ZonMw grant? 'No,' the researchers agree in unison. 'The role of chemistry in medical biology is becoming increasingly important, and we’ve worked hard to make this happen.'

Your tuition fee depends on a number of factors, such as your nationality and your previous Dutch higher-education qualifications.

Farmers on the outskirts of Nairobi National Park protect their livestock using flashing lights on top of the animal enclosures. This system keeps lions away at night. Leiden research has shown that the method is both simple and effective. Publication in PLOS ONE.

In his inaugural lecture Dennis Claessen will explain how he wants to ensure that lecturers have less admin to do.

Gilles van Wezel has been reappointed as Scientific Director at the Leiden Institute of Biology (IBL). Van Wezel has been director of this institute since September 2018 and will remain so until 1 September 2026.

Maurijn van der Zee, evolutionary biologist at the IBL, received the National Zoology Award for his research on the evolutionary success of the insects. The award was handed out last Saturday, the 17th of December, by Professor Jan Kammenga, chairman of the Royal Dutch Zoological society.

As of 1 May 2018, Nicole de Voogd has been appointed as Professor by special appointment Global change and marine ecosystems at the Institute of Environmental Sciences (CML). She is currently senior researcher at Naturalis Biodiversity Center in the field of tropical marine ecosystems.

Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…

To what extent do nanoparticles accumulate in plants and animals, and what properties of the particles play a part in this? Willie Peijnenburg, professor of Environmental toxicology and biodiversity was awarded a Marie Curie grant to conduct research on the environmental effects of nanoparticles.

Leiden scientists are the main applicants for five projects that have been awarded a Science Groot grant of up to 3 million euros in the Science Domain. In addition, several Leiden scientists are involved in other projects that have been awarded funding.

From pipetting in the lab to shining in front of the camera at a global student event. With 8.000 viewers watching the livestream, Marjolein Crooijmans presented the iGEM Giant Jamboree in Paris.

An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.

'We have to look for products that can replace ordinary disposable plastics, for example of organic material. Within 20 years, the average plastic use of a household will be largely reduced.' According to Thijs Bosker, Associate Professor at Leiden University College, in Edition NL of Tuesday, October…

The world is becoming clogged with plastic, with tiny plastic particles found everywhere, from the oceans’ depths to the mountain tops, soil, plants, animals and even inside us. The question is: what harm, if any, are they causing? In a new article on The Conversation, environmental scientists Meiru…

Leiden's iGEM team has won high honours at the Grand Jamboree in Paris. The biology students came second in the Overgraduate category with their project PHAse Out. They also took home awards for Best Biomanufacturing Project, Best Wiki and Best Entrepreneurship as well as a Gold Medal. To top it all…

Amorphophallus decus-silvae, or the ‘penis plant’ as it is known, has just flowered at the Hortus botanicus. It flowered for two days, and then the pollen, which the male flowers produced was collected. As far as the plant experts at the Hortus can tell, this was just the third time that this species…

The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…