Emeritus professors Dirk van Delft and Frits Berends both channelled their inner Sherlock Holmes as they delved into the life and work of the great physicist Hendrik Lorentz. Their voluminous biography ‘Lorentz: gevierd fysicus, geboren verzoener’ (Lorentz: celebrated physicist, born mediator) is published…

Knowledge and culture subproject 1:

From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, explore our standout discoveries and most inspiring collaborations from the past year!

Current electrochemical theory does not adequately describe realistic platinum electrodes. Scientists at Leiden University have now, for the first time, mapped the influence of imperfect platinum surfaces. This provides a more accurate picture of these electrodes, with applications in hydrogen production…

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

During the period 500–1000 CE Egypt was successively part of the Byzantine, Persian and Islamic empires. All kinds of events, developments and processes occurred that would greatly affect its history and that of the eastern Mediterranean in general. This is the first volume to map Egypt's position in…

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…

The Brain and Education lab is a research group in the Institute of Education and Child Studies at Leiden University in the Netherlands. We use a Developmental Cognitive Neuroscience approach to study the development of complex cognitive processes involved in learning and academic skills such as reading…

Promotor: Prof.dr. J.P. Abrahams

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

How can we solve value conflicts?

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

As an alternative to the diving board shaped force sensor, we are now developing a magnetically levitated small superconducting particle – or ‘Lead Zeppelin'' – as our mechanical resonator. We explore routes towards detection of gravity between small objects.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

COI@Leiden organises activities and events throughout the year. These include a monthly seminar series on topics relating to conflict resolution and PhD labs to assist COI students in developing their research skills.

The Resilience Center Leiden investigates how stress impacts the mental health of young people. For that, the team studies a multitude of factors, such as childhood experiences, the social environment, psychological factors, and neurobiological factors. With this multidimensional approach, we aim to…

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

The programme group Educational Sciences is one of the six programme groups within the Institute of Child and Education Studies at Leiden University.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

National and international actors have attempted to provide accountability for the events at Srebrenica in July 1995. This research project aims to draw lessons learned from those multiple efforts in assessing whether securing a measure of ‘justice’ for the victims has been successful and how national…

Tonal bilinguals of two closely related Chinese dialects are amazing people. They handle two tonal systems in their mind; their two vocabularies are from closely related dialects, and they write translation equivalents with common Chinese characters. Their unique language situation makes their mind…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Violence during war often involves upswings and downturns that have, to date, been insufficiently explained. Why does violence at a particular point in time increase in intensity and why do actors in war decrease the level of violence at other points? Duyvesteyn discusses the potential explanatory variables…

The Leiden Centre for Theoretical Philosophy (LCTP) is a platform for analytic philosophy in a broad sense at Leiden University. Its members do research in philosophy of science, philosophy of logic and metaphysics, with a keen interest in the history of topics such as mind, knowledge, truth, and ti…

How to explain the apparent high success rates of the EU infringement procedures, which are the major tools for enforcing EU law, against the member states?

Check back regularly on this page for research opportunities of interest to Humanities staff and students employing digital tools and methodology.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Psycho-physiological studies for health and disease.

Labbe

The Future of Multilateralism addresses current challenges and future perspectives of international and regional organizations. It aims to uncover how stable the foundations of global cooperation really are, particularly in the light of the latest unilateral and protectionist practices of international…

Promotor: Prof.dr. S.F. Portegies Zwart

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Beyond Empires explores the complexity of empire building from the point of view of self-organized networks, rather than from the point of view of the central state.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

In this paper, Kantorowicz aims to track the persistent effect of former partitioning borders on property tax rates in Poland.

Formulation of biopharmaceuticals

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: J.M. Memelink