We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: Prof.dr. M. Ubbink

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Lecture

The Cell Observatory is run by several people some of which have multiple roles. To identify whom to contact for what issue please refer to the list below

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: Prof.dr. J.P. Abrahams

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Through courses and research projects, you are trained by experts in the field.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Asexual procreation in female wasps leads to an accumulation of genetic mutations, and the shrivelling of their sex organ. Leiden biologist Ken Kraaijeveld published this discovery in Evolution. His research is one of the first experimental studies into the consequences of asexual procreation.

China’s booming aquaculture industry is increasingly dependent on fishmeal made from wild-caught fish, a practice that depletes wild fish stocks. A new study conducted by institutions including Leiden University and Stanford offers a more sustainable path. The study appeared in the journal Science on…

Oncode Investigator Mario van der Stelt and his colleagues have discovered a new potential drug that suppresses chemotherapy induced neuropathic pain.

School of pharmaceutical sciences, University of Geneva - Switzerland

Seven Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO).

PhD defence

PhD defence

New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.

Antibiotic-resistant bacteria are a major problem worldwide. Molecular biologist Changsheng Wu explored innovative methods of developing new antibiotics more simply and more easily. He also discovered a new type of antibiotic.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.

PhD defence

Research training projects in the MCBIM group - Bachelor and master students of all chemistry related studies are more than welcome to take part in our research activities. We have various research projects, all in one way or another involving transition metal ions. Daily supervision in the laboratory…

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

Students of the Faculty of Science have chosen Dennis Claessen (IBL) as the best teacher of last year.

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

Lecture

In Dutch TV programme Early Birds, Marvin and Kevin Groen (26) showed viewers areas of nature in the city that often go unnoticed. These good-natured brothers - twins, in fact - were a big hit with the viewers. How much influence do they have on one another's studies and work?

The Royal Netherlands Academy of Arts and Sciences has elected five Leiden professors from different disciplines as new members. Two of the new members are women.

The main purpose of DNAmarkerpoint is to better understand the ecology, evolution and biodiversity through the study of ancient- and modern DNA.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Centre with University of Havana.

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…

With a MSc in LST you are well prepared for a wide range of career opportunities. Life Science research and business is one of the fastest growing economic activities worldwide.

Lecture

In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

For his ground-breaking chemical biological research, a VICI-grant has been awarded to Mario van der Stelt, professor of Molecular physiology at Leiden University. In a new research line, he aims to discover binding sites for new medicines against inflammations in the brain.

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.