2,709 search results for “quantum mechanisms” in the Public website
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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Research
The research of the unit is aimed at the development of models to explain and describe the influences in social systems. Social influences are studied in three ways: from the perspective of group dynamics, from an individual-cognitive perspective, and from an economic and consumer psychological pers…
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Interkingdom Signaling between Bacillus subtilis and Sporisorium scitamineum
Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Coupled Electronic and Nuclear Dynamics at Interfaces of Artificial Photosynthesis Devices
Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Buckling on demand
Researchers from Leiden University, the Netherlands, designed a novel metamaterial that buckles on demand. Small structural variations in the material single out regions that buckle selectively under external stress, whereas other regions remain unchanged. The research is published in this week’s Early…
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Surprising vacuum forces in a superconductor
Lecture, Tuesday Talks: Science Insights
- LSWK lecture: Black holes as quantum computers and the strange matter of high-temperature super conduction
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100 Years of SPIN symposium
Conference
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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Biologics Formulation
A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…
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Gravitation grants for three major research programmes
Three major research projects involving Leiden scientists have been awarded a grant from NWO’s Gravitation Programme. The projects are on innovation processes, organs-on-chips and quantum software.
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Computational speedups and learnability in quantum machine learning
PhD defence
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Separating quantum and classical computing: rigorous proof and practical application
PhD defence
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On quantum transport in flat-band materials
PhD defence
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Hybrid Quantum-Classical Metaheuristics for Automated Machine Learning Applications
PhD defence
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Proof techniques in the quantum random-oracle model
PhD defence
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The power of one qubit in quantum simulation algorithms
PhD defence
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A quirky block of rubber as a calculator
PhD candidate Jiangnan Ding explores how you can design a thick slab of rubber in a way that it might act as a mechanical computer bit. This so-called mechanical metamaterial is pushed in a specific way to change its shape. ‘With a very simple material, we might be able to do simple calculations in…
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Leiden Celebrates Einstein’s Birthday
Exactly 138 years ago, Albert Einstein came into this world to forever change our understanding of it. The Leiden physics institute, where he frequently worked, organised a symposium in honor of his birthday.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Solving the Real Property Conflicts in Post-Gaddafi Libya, in the Context of Transitional Justice
What is the state of access to justice in real property grievances in today’s Libya, and how should it be improved?
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Questions in context: The case of French wh-in-situ
On the 4th of November, Aliza successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Aliza on this achievement!
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Developing university students’ competencies in interdisciplinary teaching contexts
How interdisciplinary teaching supports the development of students’ competencies
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The Public Dimension of International Investment Law and Arbitration
How can international investment law and arbitration take account of the public interest in, and more broadly, the public dimension of, the relations between foreign investors and host States ?
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Research
Industrial Ecology
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Like me or else...
Nature, nurture and neural mechanisms of social emotion regulation in childhood
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Early intervention and treatment prediction in childhood specific phobias: Combining one-session-treatment with app-based technology
Can a newly developed, app-based, personalized maintenance program enhance the effectiveness of the exposure-based one-session-treatment for children with a specific phobia?
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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European Union as a global security actor: common security and defence policy and its challenges in the 2011 Libya crisis and 2014 Ukraine conflict
How can the problems in establishing a sustainable common security and defence mechanism for the EU be explained?
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Zipping into Fusion
Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Taxation of Cross-border Inheritances and Donations
On 3 June 2021, Vassilis Dafnomilis defended his thesis 'Taxation of Cross-border Inheritances and Donations'. The doctoral research was supervised by Prof. F. Sonneveldt and Prof. S. Douma (UvA).
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Regulation and ICT
How does the development of digital technologies impact society, and law/regulation within that society?
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Photocatalytic redox reactions at the surface of liposomes
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Thrips resistance in Gladiolus: an eco-metabolomic approach
Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.