1,288 search results for “Polymerase chain reaction” in the Public website
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Thomas Hansen
Science
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Richard van Lent
Science
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Electrolysis and fuel production
Electrolysis is a technique that can be used to convert CO2 into fuels and other useful products. To do this efficiently and on a large scale, however, we need to understand exactly how electrolysis works. Professor Marc Koper is an expert in this field.
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Cross-craft interaction in the cross-cultural context of the Late Bronze Age East Mediterranean
In tracing intra-site, local and regional craft networks in Late Bronze Age Tiryns (Greece) the project aimed to understand technological changes, (dis)continuities and social practices from the Late Palatial until the Post Palatial periods in Mycenaean Greece.
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Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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The recent IPCC report: some reactions from our Liveable planet community
The publication of the recent IPCC report on climate change has not gone unnoticed, to put it mildly, certainly not within the Liveable Planet community.
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Key publications
Key research articles and book chapters of the Chromatin group.
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Research
The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.
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Steady-State Analysis of Large Scale Systems
Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma
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Metagenomic sequencing in clinical virology: advances in pathogen detection and future prospects
PhD defence
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Experimental project Huize Horsterwold
The project’s main aim was to build a reconstruction of a prehistoric house plan, without using any metal tools. How effective are tools made of stone, flint, bone, antler and wood? What are the constraints imposed by the various building materials? How much labour do we need and how much knowledge…
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T-DNA integration and DNA repair of DSBs in plants
Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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REEsilience
How can we ensure a more resilient and sustainable supply of Rare Earths in the EU in the future?
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Approach to Markov Operators on Spaces of Measures by means of equicontinuity
The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.
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Geometry and Topology in Active and Driven Systems
The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).
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Natalia Donner
Faculty of Humanities
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Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase
The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…
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Architecture on the move
How did people in the latter part of the Late Bronze Age organize themselves in order to be able to erect massive structures such as tholos tombs, citadels and how did they interact with these materials and circumstances while constructing? What impact did such a changing landscape have on their day-to-day…
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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Indigenous adornment in a pan-Caribbean perspective
the production, use and exchange of bodily accoutrements through the lenses of the microscope
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About the Food Citizens project
The project 'Food citizens?' examines the consequences and premises of collective food procurement in three European cities (Rotterdam, Turin, and Gdańsk).
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Bamboo
Biodiversity and trade: mitigating the impacts of non-food biomass global supply chains.
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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A recipe for desert: analysis of an extended Klausmeier model
Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk
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Master Projects
Master projects are available in
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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CO2-Calculator
Development of GHG calculator for bio-electricity and heat.
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Research
Covering the entire chain of Environmental Risk Assessment
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Break-through in the genetic modification of plants
A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…
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Laboratory for Astrophysics
We simulate interstellar clouds with special plasma expansions and chemical reactions on icy dust grains to be measured in ultra-high vacuum setups. This provides the data necessary to guide and interpret astronomical observations and to model reaction networks in space. [Harold Linnartz]
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Leiden Institute of Chemistry
The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.
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Formation of synthetic fuel: new insights!
Navarro Paredes
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Heterogenized molecular (pre)catalysts for water oxidation and oxygen reduction
Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Fast Oxygen Reduction Catalyzed by a Copper(II) Tris(2‐pyridylmethyl)amine Complex through a Stepwise Mechanism
The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…
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SETinSTONE
A retrospective impact assessment of human and environmental resource usage in Late Bronze Age Mycenaean Monumental Architecture, Greece
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Criminal Justice: Legitimacy, Accountability and Effectivity
How can and should tasks and competences for the purpose of the criminal justice system (i.e. legislation, enforcement, the administration of justice and sentencing) be defined and formulated, factoring in the chain concept, adjoining national and international legal domains and standards arising from…
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Unfolding secrets of catalysts
To construct catalysts that can produce fuels from CO2 innumerable times, we need to learn much more about how catalysis works. Irene Groot is conducting groundbreaking research into catalysis at the atomic level.
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near-surface environment in tuning electrochemical CO2 reduction reaction and H2 evolution reaction
PhD defence
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CO oxidation catalysis at multiple length scales
Promotor: J.W.M. Frenken, Co-Promotor: R. Felici
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Bio-inspired Computing
We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.
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Accessing End-Of-Supply Risk of Spare Parts Using Big Data
How to access the end-of-supply risk of spare pares using big data analytics
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CERA - Certification of Raw Materials
CERA (CErtification of RAw Materials) is a four-year project that will develop a standardized certification scheme ensuring environmental, social and economic sustainability in extraction, processing, trading and manufacturing of all mineral raw materials. It will guarantee traceability of certified…
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The Metals Programme
Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.
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Biomolecular analyses of skeletal remains in the circum-Caribbean across the historical divide (A.D. 1000-1800)
As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.