1,288 search results for “Polymerase chain reaction” in the Public website
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Accurate Probabilities for Highly Activated Reaction of Polyatomic Molecules on Surfaces Using a High-Dimensional Neural Network Potential: CHD3
An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…
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Nanoparticles: shapeshifters that pass along the food chain and end up in the brain
Nanomaterials can pass much further along the food chain than was previously thought. The particles can change shape and size in each organism, enabling them to pass on to the next one in the chain. Researchers from the Institute of Environmental Sciences discovered this accidentally when using a novel…
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Early Colonial Mosaics, Transculturation within Ceramic Repertoires in the Spanish Colonial Caribbean 1495-1562
What can continuity and change in the manufacturing of locally made ceramics from the early colonials Spanish towns of Concepción de la Vega, Cotuí and Nueva Cádiz (1492-1600) tell us about the choices people made in ceramic production as a reaction the the changing social environment?
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Ludo Juurlink
Leiden Learning and Innovation Centre
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Geert-Jan Kroes
Science
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Fate, accumulation and impact of metallic nanomaterials in the terrestrial environment
The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.
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Researching global inequality in the garment commodity chain
A consortium, led by Erik de Maaker (CADS, Leiden), has under the NWA scheme (Dutch National Science agenda) been awarded 98k€ for Localizing Global Garment Biographies, a two-year project to research the different ways by which users and producers attach value to garments.
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Catalysts contribute their own oxygen for reactions
A catalyst: normally a substance that speeds up a chemical reaction, without adding molecules to this reaction. Scientists from the group of Prof. Marc Koper of Leiden University and Prof. Yang Shao-Horn of MIT now discovered that in specific reactions that need oxygen, catalysts called metal oxides…
- Publication highlights
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Knowledge of DNA repair in the fight against tumour cells
What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.
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Fundamental research on the voltammetry of polycrystalline gold
Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Reactivity of cobalt(II)-dichalcogenide complexes: correlation between redox conversion and ligand-field strength
The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.
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Reconstructing Object Biographies
We live in a world of things and people in the past must have been as closely entangled with their material surroundings as we are now. In the Laboratory for Artefact Studies Van Gijn takes a close look at the biographies of objects: what kind of raw material an object is made off and what is its provenience,…
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Topology of polymer chains under nanoscale confinement: insights into genome folding
This month, a paper was published in Nanoscale by scientists from Dr. Alireza Mashaghi group at the Systems Biomedicine and Pharmacology Division in collaboration with the group of Dr. Sander Tans from TU Delft/AMOLF. In this paper, the authors studied how nanoscale spatial confinement affects the fold…
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contribution to the development of African countries in the global value chain
Economies worldwide are increasingly interconnected; trade in raw materials and semi-finished products is increasing. Many products we use in the Netherlands originate abroad, and many products we make in the Netherlands are destined for other countries. Almost all countries around us participate in…
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Two thesis awards for research on electrochemical reactions
Understanding the proces of electrochemical reactions is essential to improve the technology for the energy transition. Fuel cell cars, for example use hydrogen produced from the electrolysis of water. Mariana Monteiro did fundamental research on the process and won two prizes with her thesis.
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Selectivity and competition between the anodic evolution of oxygen and chlorine
Sustainable energy from wind and solar is most readily available near the sea.
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Jeu d'argile: céramique, indentité culturelle, créolisation
Une étude archéo-anthropologique de la céramique des sociétés caribéennes multiculturelles de la période précoloniale à nos jours
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theory highlights the importance of substrate flexibility in enzymatic reactions
Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…
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Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
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I think that we can establish the best eye radiation chain in the world
Annually, approximately 60.000 people in the Netherlands undergo radiation therapy for cancer. Coen Rasch is dedicated to enhancing the precision of proton therapy.
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Overcoming the Debye screening length with radiofrequency-operated graphene biosensors
Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?
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Publications
Relevant publications of the CIGR participants.
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Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Catalysis of the electrochemical water oxidation to oxygen
Promotor: M.T.M. Koper, Co-Promotor: F. Calle-Vallejo
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Design of homogeneous water oxidation catalysts
To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.
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Non-adiabatic effects may substantially affect rate of reaction relevant to Haber-Bosch catalysis
Using N2 dissociation on Ru(0001) as a representative showcase (for catalysts employed in the Haber-Bosch process), we have shown for the first time that non-adiabatic effects can substantially reduce a molecule’s dissociation probability on a metal surface. These effects are currently completely unaccounted…
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The Chains of Holland’s Glory: research into South Holland's slavery past completed
Karwan Fatah-Black and Lauren Lauret are co-authors of Geketend voor Hollands Glorie (The Chains of Holland’s Glory) that studies the political and economic connections between South Holland and slavery. The findings of this research will be presented with Dr. Joris van den Tol (Radboud University)…
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Maarten Koese
Science
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Susan van den Brink
Science
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Catrin Böcher
Science
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Electrocatalysis of CO2/CO interconversion and Hydrogen Evolution in Bicarbonate Buffers
Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.
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Cutaneous barrier dysfunction in atopic eczema: the role of stratum corneum lipids
Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463
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Award-winning thesis reveals gender gap in reactions to women’s sexual assault stories
Research master student Linda Bomm found in her thesis that men, compared to women, believe female sexual assault survivors less, blame women more, and judge them more negatively – especially if they identify strongly with their male gender.
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Unlocking the chemistry of the heavens
How are the building blocks of life formed?
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Travelling waves on trees and square lattices
In this thesis we study bistable reaction-diffusion equations on lattice domains.
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Exploring structure dependencies of gas-surface interactions with curved single crystals
Curved single crystals provide variable, but well-defined surface structures.
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Coen van Hasselt
Science
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Nanoparticle – redox protein biohybrids
Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology approaches. We aim to develop hybrid systems between light-harvesting nanoparticles and redox-enzymes (oxidoreductases)…
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Islam in the West
Muslims have lived in Eastern and South-Eastern Europe for centuries. Their arrival in Western Europe, the two Americas and Australia is however relatively recent. Studying how Muslims relate to their Western environment (and vice versa) and the mutual influences of Western and Islamic philosophies…
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Noisy Patterns: Bridging the gap between stochastics and dynamics
In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…
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Research
Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…
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an accurate predictor for variation with geometry of barriers for reactions on metals
A semi-empirical version of the specific reaction parameter approach to density functional theory (SRP-DFT) has been remarkably successful at predicting dissociative chemisorption probability vs. incidence energy curves for reactions on metal surfaces. New quantum Monte Carlo (QMC) calculations on the…
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Deciphering the complex paramagnetic NMR spectra of small laccase
Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.
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Chinese tobacco industry more likely to turn you into a drinker than a chain smoker'
This remarkable statement appears in Yi-Wen Cheng’s dissertation on state monopoly and forms of competition in the Chinese tobacco industry. Cheng presents her conclusions and looks back on her fieldwork. ‘I had to accept a lot of drinks in order to establish a network of contacts.’
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Sabine Auras
Science