346 search results for “Oliphant Mrs Margaret 1828 1897 Young Musgrave A novel” in the Public website
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.
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A novel biofilm for skin barrier repair of patients with atopic eczema
Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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Advanced Pre-clinical Evaluation of the Guanidino Lipoglycopeptides: A Novel Family of Glycopeptide Antibiotics with Best-in-Class Potential
Can we make a better vancomycin?
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as
Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as meditation and yoga.
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Identification of novel targets in prostate cancer progression
Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen
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Writing Novels under the New Order
On the 31 March 2022 Mr. Taufiq Hanafi successfully defended a doctoral thesis and graduated.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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A novel approach to measuring firms’ R&D performance
As an R&D manager, how can you measure the R&D (research and development) performance of your firm? How does knowing the importance of different R&D measures allow R&D managers to formulate more effective strategies to improve their firm’s R&D performance?
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Words and Laments: A Narratological Analysis of Esmāʻil Fasih’s War Novel, The Winter of 1983 (Zemestān-e 62)
Saeedeh Shahnahpur defended her thesis on 13 September 2016.
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Replacing fear with something new: Using novelty to unlearn fear.
This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.
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Novel set in Ehrenfest house
Leiden alumnus and writer Tomas Lieske has published a novel which is set in the house of Paul Ehrenfest. Ehrenfest was a famous physicist who organized round table events every Wednesday evening at his home in Leiden in the early twentieth century. The big names from modern physics frequented these…
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Student projects
Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…
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A novel approach towards acute care integration
PhD defence
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Young Academy Leiden - Citizen Science workshop by Margaret Gold
Workshop
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Quantum Lab (aQa)
Quantum computing is a novel paradigm for computation, which is nearing real-world impact with the coming generation of limited, but nonetheless powerful quantum devices.
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Novel detection method for iron in Alzheimer’s brain
For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Optimality
Optimality in plant properties and processing.
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Crisis and change in European Union foreign policy
How do crises produce changes in specific European Union foreign policy areas, and how should we conceptualise these policy changes?
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Between life and death: organizational change in central state bureaucracies in cross-national comparison
Identifying and explaining change in the structure of central state bureaucracies and the determinants of survival of individual public organizations are two closely related areas of research in public administration. We aim to bridge the gap between these two main strands of studies of organizational…
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Moved by the tears of others: emotion networking in the heritage sphere
There is no heritage without emotional sharing and clashing. This article explores the involvement of divergent emotions in heritage making by discussing the debate series of Imagine IC and the Reinwardt Academy and zooming in on the commemoration of slavery and imagery of ‘Black Pete’ in the Netherlands.…
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Bio-inspired Computing
We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.
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Film and Literary Studies (BA)
Do you enjoy a great story? In the Bachelor's programme Film and Literary Studies at Leiden University you study the stories behind the stories. Because what makes a novel fascinating or a horror movie frightening? Study film, literature and media from around the entire world and discover the differences…
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Personalized Medicine
Assessing and implementing new diagnostics strategies for stratifying patients
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Single-electrolyte isotachophoresis: on-chip analyte focusing and separation
Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto
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Cell Therapy
Decision support tool for cell therapy commercialization and business development
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AI application in pathology reveals novel insights in endometrial cancer diagnostics
Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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TRAFIG: Transnational Figurations of Displacement: Connectivity and mobility as solutions to protracted refugee situations
How can we promote more durable solutions to protracted refugee situations and which roles can connectivity and mobility of displaced people play to improve protection and resilience?
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The Implications of ISIS (the “Islamic State”) for Islamic Movements and the Middle East
Political Islam is not new to the Middle East, but the appearance of ISIS has stretched the phenomenon to the extreme.
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Topic: Novelty and enrichment
One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Knots in plasma
A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.
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Turtles all the way down: multiscale simulations connecting star and planet formation
The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.
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Rethinking Political Obligation. Moral Principles, Communal Ties, Citizenship
Why obey the state? Dorota Mokrosińska presents a fresh analysis of the most influential theories of political obligation and develops a novel approach to this foundational problem of political philosophy, an intriguing combination of the elements of natural duty and associative theories.
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Liposomes as delivery system for allergen-specific immunotherapy
In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.
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Development of homogeneous catalysts for the selective conversion of levulinic acid to caprolactam
Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent
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Egypt beyond representation
This research develops and applies a new approach to study Aegyptiaca Romana from a bottom-up, Roman perspective.
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An analytical framework for postmortems of European foreign policy: should decision-makers have been surprised?
This paper develops a novel theoretical framework for the conduct of postmortems after major foreign policy surprises for the European Union and its member states.