173 search results for “Liu Huogong” in the Public website
-
Key publications
Key publications of the Quantitative Pharmacology group
-
Allosterism
The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…
-
Pascal chair at LIACS
The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.
-
The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
-
Institute of Biology Leiden
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.
-
Latency, Energy, and Schedulability of Real-Time Embedded Systems
Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.
-
The Roots of Intentionality in Aristotle´s Theory of Psychology
The relevance of intentionality to the interpretation of Aristotle was first suggested by Brentano in his Psychology from an Empirical Standpoint. Here we take our starting point from Brentano and investigate how Brentano’s concept of intentionality is rooted in Aristotle.
-
Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists
Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.
- Leiden Academic Centre for Drug Research
-
Luminescence and applications of lanthanoid coordination polymers
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
-
Bearing with noise: The effects of highway noise on behaviour and development in zebra finches
Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.
-
Identification of productive and futile encounters in an electron transfer protein complex
PNAS publication on protein encounter complexes
-
Projects
Research projects
-
Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
-
Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
-
Gauge theory and nematic order : the rich landscape of orientational phase transition
Promotor: J. Zaanen
-
Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
-
Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
-
Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
-
Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
-
Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
-
A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits
Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)
-
About
Leiden University Centre for Intercultural Philosophy (LUCIP) is a centre housed in the Institute for Philosophy at Leiden University.
-
Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
-
Lipid signaling in brain diseases
Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].
-
Smart Industrial Parks in China: towards Joint Design and Institutionalization
How to contribute to a quantum leap of eco-industrial symbiosis in China?
-
Allosteric Modulation
Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…
-
Publications
For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.
-
Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein
Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)
-
To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
-
Faculty of Science
Explore the unknown in order to be able to innovate in the distant future.
-
New treatments for life-threatening disease sepsis
Due to the increasing resistance to certain antibiotics, the life-threatening condition sepsis is becoming harder to treat. For her PhD project, Leiden pharmacologist Feiyan Liu used mathematical modeling to find out how antibiotics can be used more effectively to cure sepsis.
-
Breakthrough artificial photosynthesis comes closer
Imagine we could do what green plants can do: photosynthesis. Then we could satisfy our enormous energy needs with deep-green hydrogen and climate-neutral biodiesel. Scientists have been working on this for decades. Chemist Chengyu Liu will receive his doctorate on 8 June for yet another step that brings…
-
Doctors and citizens under fire in conflict zones
It is time for the international community to put a stop to war crimes – especially against medical personnel, argued international chair of Doctors Without Borders Joanne Liu in her Cleveringa lecture.
-
Developing drugs with artificial intelligence
Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.
-
International President Médicins Sans Frontières visits LUC The Hague
Last Thursday , Dr. Joanne Liu, the International President of the Médicins Sans Frontières (Doctors without Borders), visited LUC The Hague as part of her visit to Universiteit Leiden. Dr. Liu spoke with four of our students, who shared their experiences as volunteers working with refugees all over…
-
How oxygen deprivation causes cancer cells to spread
In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…
-
The role of auxin in somatic embryogenesis
What is the role of auxin in the initiation and process of somatic embryogenesis?
-
Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling
The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…
-
PhD Theses
A full overview of MacBio PhD Theses.
-
PhD Theses
A full overview of MCBIM PhD theses.
-
Awards
These honors and distinctions were given to work that was done within the Media Technology program by both students and staff.
-
Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
-
Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
-
Student life
The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!
-
Binding kinetics
A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…
-
New carbon membrane generates a hundred times more power
Leiden chemists have created a new ultrathin membrane only one molecule thick. The membrane can produce a hundred times more power from seawater than the best membranes used today. The researchers have published their findings in Nature Nanotechnology.
-
Publications
Below is a chronological list of the most recent to oldest publication from the MultiGreen project.
-
Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
-
Minister overhandigt eerste exemplaar boek Pablo Mendes de Leon en Niall Buissing
The Dutch Minister for Infrastructure and Watermanagement Cora van Nieuwenhuizen has offered the first copy of the book ‘Behind and Beyond the Chicago Convention: The Evolution of Aerial Sovereignty’ to the Secretary-General of the International Civil Aviation Organization (ICAO).