Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Saeedeh Shahnahpur defended her thesis on 13 September 2016.

Nuran Buket Cengiz defended her thesis on 13 June 2017

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

How do academics develop into novel researcher roles alongside current teacher roles in the context of new universities in transition?

Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…

On 30 January 2024 Jurre van der Meer successfully defended a doctoral thesis and graduated.

How can zebrafish research help to understand and fight human cancer?

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

The mission of Software and AI in Business (SA&B)connects the domains of science, business, and policy. Scientific research we focus on at Leiden in areas such as artificial intelligence promises to reshape our societies for the better. Translating science into positive societal impact however requires…

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

How does the management of Elephant Marsh Fishery in Malawi relate to wider contexts of policies, theories and regions? And how can the current management system be adapted to achieve long-term sustainability of the fishery?

This project aims to identify which aspects of exploring a novel environment produce beneficial effects on memory. The effects of novelty will be investigated across the lifespan, including children, adolescents and older adults.

Promotor: B. van de Water

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Cardiovascular disease is the leading cause of death worldwide.

Research projects

Promotor: Prof.dr. G.P. van Wezel

Key publications of the Computational Drug Discovery group

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

Can excessive worrying be reduced via stimulation of the vagus nerve?

Relevant publications of the CIGR participants.

Key publications of the Predictive Pharmacology group.

On 21 March 2019, James Welch defended his thesis 'The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism'. The doctoral research was supervised by Prof. dr. P.B Cliteur.

Source: J Med Chem (2015)

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: Prof.dr. J.W.M. Frenken

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.