The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.

Promotor: Prof.dr. H.L.V. Linnartz

Conference

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

The aim of the Standard Operating Procedures for Research Integrity (SOPs4RI) project was to promote excellent research and a strong research integrity culture that aligns with the principles and norms of the ‘European Code of Conduct for Research Integrity’, and to counter research misconduct. The…

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

Research report January 2020. Supported by the lectorate ‘Music, Education and Society’, research group ‘Making in Music’, Royal Conservatoire The Hague

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Dishoeck

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

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Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

On the28th of September Didi van Trijp successfully defended a doctoral thesis and graduated.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

They hurtle along at over a thousand kilometres per second: the fastest stars in the Milky Way. PhD candidate Fraser Evans conducted research into these elusive hypervelocity stars and discovered that they have a lot to teach us, about black holes and supernovae, for example.

Lecture

An Investigation into the role of copper-alloy craft production in the early medieval economy of northwest Europe.

A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.

‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

How did learned natural historical inquiries into the underwater world develop in eighteenth-century Europe?

The symposium is open to all registered participants and consists of two sessions and a Poster Session.

The aim of ANCIENT CHARM was to develop neutron-imaging techniques and the associated equipment, and help establish neutron imaging as a mainstream archaeological analytical technique. In particular, one of the goals was a new imaging technique which called neutron resonant capture imaging combined…

The 2015 Dissertation Prize of the Global Neutrino Network has been awarded to Tri Astraatmadja, who was part of the Leiden/Nikhef ANTARES group during his PhD research. Astraatmadja receives the award for his thesis 'Starlight between the waves: In search of TeV photon emission from Gamma-Ray Bursts…

The emergence of metalwork deposition during the Bronze Age in Northwest Europe, c. 2300-1500 BC

Recent welfare reforms in the Netherlands show a trend of reducing welfare accessibility and increasing obligations. Although the effects thereof on directly-targeted economic outcomes, such as welfare dependency and labor participation, are often assessed, potential spillovers to other economic and…

Current research at the Skin Barrier and Vaccination group.

Researchers from Leiden and Delft have found a way to look inside early-modern bookbindings. An x-ray technique has allowed them to search for remains of medieval manuscripts hidden inside the bindings. After the Middle Ages many manuscripts were recycled, their pages pasted inside bookbindings to provide…

Dust particles in space form the basis for new stars and planets. But what do these particles consist of and how do they behave? Sascha Zeegers studied this. PhD defence 1 November.

Leiden Institute of Advanced Computer Science (LIACS)

A couple of years ago, theoretical physicist Carlo Beenakker tracked down the Majorana particles and inspired Leo Kouwenhoven from TU Delft to try to create them in a superconducting nano-structure. He succeeded in doing so in 2012, and the news made headlines around the world. But a lot of work still…

This project embarks on empirical analysis of popular psycho-physical practices in contemporary Korea.

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Studying in The Hague can make a big difference. The Hague is proud to be known as the international city of peace and justice. The city is full of opportunity and is a fantastic student city.

Coordination chemistry is the chemistry of metal atoms

‘No choice is forever’, states Tracy Evans. ‘You can change your mind and go in a different direction when the circumstances change.’ When Tracy was 60 years old, she felt the need for a change herself. It lead to her earning a PhD degree six years later.

From 12 – 16 May, prof. Fokkens and five RMA students (Kiki de Bondt, Jordy Aal, Mette Langbroek, Gwendolynn de Groote and Bastiaan Steffens) visited Cambridge for a two-day workshop with prof. Marie Louise Sørensen, staff and students of Cambridge University, and a number of the members of the Cambridge…

Richard Barrett has launched a new digital music label on Bandcamp.

It is theoretically possible that habitable planets exist around pulsars, rotating neutron stars. Such planets must have an enormous atmosphere that convert the deadly X-rays and high energy particles of the pulsar into heat. That is stated in a scientific paper by astronomers Alessandro Patruno and…

How do stars and galaxies form? What is dark matter? To answer these and other questions, we need increasingly large telescopes. And to build these, we need international partnerships. A series on the impact of collaboration.

The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…

For over a year now, the James Webb Telescope has been sending stunning images that exceed astronomers’ expectations. The photos are fascinating to see, but what exactly are we looking at? Assistant professor Melissa McClure explains.

Two things are needed to produce fuel from sunlight: an antenna that harvests light, and a light-driven catalyst. The most efficient antennae contain bacteria. An international team headed by Huub de Groot imitated them and discovered how they function.

Many astronomers suspect that most of the matter in the universe is invisible. So how can you weigh dark matter if you can't actually see it? Professor Henk Hoekstra is looking for a solution. Inaugural lecture 25 June.