What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.

How can zebrafish research help to understand and fight human cancer?

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

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The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Mechanisms fro drug resistance

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The Faculty of Medicine

Wil jij meer weten over de master Geneeskunde? Bekijk dan de video van de Master Online Open Dagen waarin vertelt wordt wat je kunt verwachten van deze master opleiding.

This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Are you thinking about studying Biology? Learn more and watch the videos.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

Promotores: J. Jonkers, K.E. de Visser

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

This programme video is presented in Dutch

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Getting personal

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

The master’s programme Biology at Leiden University offers seven specialisations ranging from Cell Biology to Molecular Genetics. The programme prepares you for a career in research within or outside academia.

Biology is the study of life. Are you interested in understanding life, from the molecular level to entire ecosystems? Do you want to use your understanding and knowledge of biology to benefit the health of both humans and the environment? If so, Biology is the right study programme for you.

Assessing and implementing new diagnostics strategies for stratifying patients

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…