All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotores: J. Jonkers, K.E. de Visser

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

This article explores how to think about solidarity, considering the diverse stories, spaces, practices, bodies, and temporalities that shape a city.

Schemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information.

This doctoral research project in design seeks to shed a light on legibility in the context of visually impaired beginning readers.

On 5 September, Elize de Mul defended the thesis 'Digital Döppelgangers: identity in the Culture of Imagination'. The doctoral research was supervised by Simone van der Hof and Esther Keymolen.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Leiden University was founded in 1575, thanks to William of Orange. According to tradition, he founded the University to reward the citizens of Leiden for their resistance to the Spanish occupiers.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

EuDEco (Modelling the European Data Economy) is a Coordination & Support Action (CSA) receiving funding from the European Union’s Horizon 2020 programme.

Get the most out of your studies at Leiden University by taking part in our extracurricular activities.

Promotor: C.W.J. Beenakker, Co-Promotor: A.R. Akhmerov

Promotor: Prof.dr. M.K. Richardson

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

-

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

The world we live in is changing in many aspects at an ever-increasing speed. And it will continue to do so. How do we anticipate these changes, such as the increase in atmospheric CO2, the extinction of species and industrialisation?

Get the most out of your studies at Leiden University by taking part in our extracurricular activities.

The broad scope of the Astronomy and Instrumentation specialisation provides you with an MSc level training highly sought after by employers, not only in astronomical instrumentation, but also in other areas of high-tech instrumentation development.

Get the most out of your studies at Leiden University by taking part in our extracurricular activities.

Many students receive their first job offer during or right after their Business Studies internship. With an MSc in Physics you are well prepared for broad array of career prospects in research or industry.

Get the most out of your studies at Leiden University by taking part in our extracurricular activities.

This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…

Director: Dr. Fred Leemhuis

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Article by Dennis Broeders in the Journal of Cyber Policy on the (im)possibilities of addressing election interference and the public core of the internet in the UN GGE and OEWG.

Get the most out of your studies at Leiden University by taking part in our extracurricular activities.

Get the most out of your studies at Leiden University by taking part in our extracurricular activities.

Most of the PhD graduates (about 70 percent) find a job outside of academia. The majority of them successfully embark on a career in education, administration, heritage, journalism, or business. Other PhD graduates find employment in an academic or semi-academic environment. A considerable number of…

Promotor: J. Zaanen

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Do you have broad interests and enjoy doing more besides your regular schoolwork? Then you probably always want to know the ins and outs! That is exactly what the Pre-University College is: an extra programme for students who want and are able to do more.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Moot Court: An academic skills training course

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

It is essential for researchers to be able to obtain independent research funding in order to advance in their career.

Promotores: G.W. Canters, T.J. Aartsma

A stimulating, international and inclusive learning community is a place where everyone is welcome and where we get the best out of our students. We focus on problems that transcend borders and have a global impact; we welcome a range of perspectives; and we conduct internationally comparative resea…

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

A study of the technology, form, function, and use of pottery from the settlements Uitgeest-Groot Dorregeest and Schagen-Muggenburg 1, Roman Period, North-Holland, the Netherlands