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Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

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Promotor: Prof.dr. J. Kuiper

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Why do many medical institutions struggle to use AI in their clinical practice? What are the essential steps for and before an effective implementation of AI in radiology workflow? How can AI implementation trigger enduring improvements in the clinical process? The book shows how change management is…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

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Prostate cancer (PCa) is one of the most prevalent cancer in males.

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An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

The potential of liposomal cancer vaccines

The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

After graduation you have a lot of opportunities: academics are highly sought after in Dutch secondary education or mbo teaching. You can also aim for a management position or work as a researcher within the field of Life Sciences.

In the Master’s programme Research in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: Prof.dr. J. den Hertog

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

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As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Key publications of the Biologics Formulation group

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Assessing and implementing new diagnostics strategies for stratifying patients

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…