We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Politically speaking, the Frisian coastal area constitutes a special case in late medieval Europe since it was not subject to an overlord as it withstood feudalization in the 13th century. Its many sub regions, which were dominated by elites of small noblemen and freeholders, long time succeeded in…

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Magistri Symonis (?) Questiones secunde partis Doctrinalis Alexandri de Villa Dei First Critical Edition from the Manuscript with Introduction, Appendices and Indexes

The decades around 1800 constitute the seminal period of European nationalism. The lin­guistic corollary of this was the rise of standard language ideology, from Finland to Spain, and from Iceland to the Habsburg Empire. Amidst these international events, the case of Dutch in the Netherlands offers…

Madeleine O. Hosli, Professor of International Relations, wrote this book in which she analyses the complex relations between the European Union (EU) as a regional organization and the United Nations (UN) as an international, global governance institution.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

This book asks what it means to think globally about world politics. In an attempt to contextualise the recent ‘globalising turn’ in International Relations (IR), it takes stock of more than 30 years of efforts at addressing IR’s Eurocentric limitations, and explores what ‘thinking globally’ means in…

'Communal Dining in in the Roman West' explores why the practice of privately sponsored communal dining gained popularity in certain parts of the Western Roman Empire for almost 300 years.

The Pioneer Years of the National Museum of Antiquities in Leiden, 1818-1840

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

On 18 september 2018, Claudia Bouteligier defended her doctoral thesis 'Dialoog in recht en literatuur. The doctoral research was supervised by Prof. mr. dr. A. Ellian.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Covering all seven countries on the isthmus, this volume presents the first collection of original linguistic studies on Central American Spanish varieties, which have long been neglected in Hispanic Linguistics.

This book examines how Muslim communities in the Netherlands perceive and experience extremism, counter-radicalisation policies, and Islamophobia.

Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Language Use, Usage Guides and Linguistic Norms will be of interest to scholars of language use in both the past and the present, as well as to anyone interested in the interplay between actual language use and prescriptive attitudes towards language.

Steven Frost defended his thesis on 6 June 2017

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.

This book celebrates Maarten Mous, professor of African Linguistics at Leiden University.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The abundance of images in our everyday lives-and the speed at which they are consumed-seems to have left us unable to critique them. To rectify this situation, artists such as Daniel Richter, Jaune Quick-to-See Smith, and Artur Zmijewski have demonstrated that painting is brilliantly equipped to produce…

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

A Spanish translation of Herman Paul’s 'Key Issues in Historical Theory' has appeared under the title 'La llamada del pasado: claves de la teoría de la historia'.

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

This research is driven by the necessity to investigate the subject of performing instrumental works by Russian post-minimalist composers, and to explore possibilities of incorporating the spiritual ideas that informed those works in a concert practice.

This thesis introduces the concept of

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

On 28 June, Jakob Tobing defended the thesis 'The essence of the 1999-2002 constitutional reform in Indonesia: remaking the Negara Hukum. A socio-legal study'. The doctoral research was supervised by Jan Michiel Otto and Adriaan Bedner.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

A MSCA Global Fellowship that aims to explore the socioeconomic and environmental implications of a Latin America circularity transition, and its impact on the EU and global economy.

His instrument, his technique, his music and his life

This book presents the transcriptions and annotated translations of fifteen key historical documents concerning the Tapuia indigenous people written just before and during the Dutch occupation of northeastern Brazil.

On 25 October 2018, Tu Zhang defended her thesis 'Public Reason Secularism: A Defense of Liberal Democracy'. The doctoral research was supervised by prof. P. Cliteur.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Mechanisms fro drug resistance

Within the Leiden University Medical Center (LUMC) several research projects use pathogenic microorganisms of risk group 3. For working with these pathogens, the LUMC has a high containment research lab to safely perform the experiments for man and environment.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In the wake of controversial disclosures of classified government information by WikiLeaks and Edward Snowden, questions about the democratic status of secret uses of political power are rarely far from the headlines. Despite an increase in initiatives aimed at enhancing government transparency – such…