This book surveys a distinct human phenomenon in the history of the ancient Near East: individuals who were born males but, under various social and historical circumstances, their masculine identity was considered ambiguous. They bore specific titles and were engaged in cult or palace administration.…

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Supervisor: P.J.J. Hooykaas

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

Les Cottés is one the rare site in western Europe with occupations in sequence by the very last Neandertals and the first anatomically modern humans.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotor: S.M. Verduyn Lunel

Green infrastrucuture (GI) like urban farm and green roofs could provide many beneficial functions in cities. These include for example food production, flood prevention or increasing biodiversity. MultiGreen project aims at developing an integrated modelling tool to support…

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

On the 20th of June, Camil Staps successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Camil on this achievement!

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

This study explores regional variation in the use of utterance-final particles by analyzing spoken Taiwan Mandarin data recorded from spontaneous conversations.

The recently published book ‘Avian Cognition’ is the first multi-author book to provide a comprehensive treatment of the cognitive abilities of birds and how they compare to those of other animals. Carel ten Cate, professor of animal behavior at the Institute of Biology, and Susan D. Healy (StAndrews…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

The Directorate-General Police, Sanctions, and Protection has initiated this research project in order to gain insight in the nature and, if possible, the extent of the developments with regards to the pluralization of policing functions in the Netherlands in support of future policies for the benefit…

This study presents the findings of a laboratory-based experiment testing hypothesised processes implicated in the prevention of violent radicalisation through counter-narratives. The central aims of the study were to contribute to counter-narrative theory, whilst highlighting the value of experimental…

During the course of drug discovery translational steps are made.

Morality, mathematics, geometry, geography, music, navigation, and language are traditionally viewed as uniquely human cultural achievements and abilities. The study of their development and variation is classified as part of the humanities and social sciences. These fields have been mainly studied…

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Fred Janssen is curious about how best to teach students and students to gain a good understanding of complex ‘swamp situations’. This is the subject of his inaugural lecture as Professor of Science Education at the ICLON and the Faculty of Science. Inaugural address 19 June 2017.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.