The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Develop EPR instrumentation and methodology to investigate intrinsically disordered proteins (IDPs).

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Promotor: J.N. Kok, Co-promotor: F.J. Verbeek

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

In developing cooperation with Indonesia, Leiden University focuses on projects that benefit culture, nature, society and economy, in Indonesia as well as in the Netherlands.

Leidse milieuwetenschappers doen onderzoek naar microplastics, bestrijdingsmiddelen en bemesting. En binnenkort naar lichtvervuiling en nieuwe materialen uit de nanotechnologie.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The new building for the Faculty of Mathematics and Natural Sciences is a significant milestone for Leiden University and the faculty in particular. A new building is being realized in three phases. The first phase of the new building was put into use in 2016 and covers an area of 45,000m2. The second…

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Biospirits is the staff association for all employees and guest-employees of the IBL.

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

The Faculty of Humanities consist of various academic fields. What is the common ground of all these different academics and students? They tell their story and why it matters in today’s world in 'We are Humanities'.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

The specialisation High-Tech Innovation is for MSc students in Sciences who are interested in interdisciplinary technologies and research related to /important for high technology industries, e.g. the semi-conductor industry or nano-fabrication. In addition to their primary field of study, students…

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

On Tuesday 4 September, in a full lecture hall C1, Dean Geert de Snoo opened the Academic Year for the Faculty of Science. A year in which the ethics and responsibility of scientists will be invoked.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

This project traces how, why, and under what circumstances scholars invoked the trope of “dogmatism,” especially in controversies. Relevant controversies from various fields, periods, and countries will be subjected to in-depth rhetorical analysis.

Organisation of the Leiden Institute of Physics.

This project analyzes to what extent hodegetical textbooks relied on each other in warning their readers against vicious habits, how much continuity their catalogs of vice displayed, and to what extent vices that persisted throughout the 18th and 19th centuries were associated with easy-to-remember…

On 27 June 2019, Barry Bussey defended his thesis 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. The doctoral research was supervised by Prof. dr. P.B. Cliteur.

This research project focuses on the thoughts of ethnicity and political orthodoxy in Medieval China by investigating Wang Tong’s works.

Sound & Score brings together music expertise from prominent international researchers and performers exploring the intimate relations between sound, score and notation, and the artistic possibilities that this relationship yields for performers, composers and listeners.

Global climate change is manifest by local-scale changes in precipitation and temperature patterns, including the frequency of extreme weather events (EWEs). EWEs are associated with a myriad range of adverse environmental and societal consequences, including negative impacts to agriculture and food…

The Intelligence and Security research group focuses on intelligence and security within the European Union. Its approach is interdisciplinary and reflects ISGA’s broad perspective, combining insights from ethics, history, law, political science, psychology, and sociology.