2,349 search results for “sociale safety” in the Public website
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eLaw publishes self-assessment tool on age assurance for the European Commission
Simone van der Hof, Professor of Law and Digital Technologies at eLaw, and Mohammed Raiz Shaffique, researcher and PhD candidate at eLaw, have published a self-assessment tool on age assurance for the European Commission.
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Student for a Day - MSc Crisis and Security Management, spec. Governance of Crisis
Study information
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Student for a Day - MSc Crisis and Security Management, spec. Governance of Crisis
Study information
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Anke KleinFaculty of Social and Behavioural Sciences
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Ellen de BruijnFaculty of Social and Behavioural Sciences
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Fine Mechanical Department
What is the Fine Mechanical Department?
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Valuing archaeology
Past, Present and Future of Nubian Communities in Sudan
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Final project of the course Social and Ecological Activism in the Visual Arts (minor CSSC)
On 14 December 2022, students of the course Social and Ecological Activism in the Visual Arts (as part of the Creative Strategies for a Society in Change minor) presented and performed their final collective project at BAK, basis voor actuele kunst, Utrecht: the Water Cultures Institute group role-playing…
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Crafting networks in early farming societies
Tracing the residues of Neolithic activities through the study of stone artefacts
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Dynastischer Nachwuchs als Hoffnungsträger und Argument in der Frühen Neuzeit
This volume sheds light on the role played by progeny in maintaining dynasties in early modern royal courts as well as the horizontal and vertical interplay between the actors. It attempts to break through the narrative of older research that saw dynasties as a series of male rulers. Instead, these…
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Incentive-Based Physical Activity Programs for Cardiovascular Disease Patients
Promoting sustained physical activity through tailored incentive-based interventions for diverse cardiovascular disease patient groups.
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15 million awarded for research into misinformation among youth
Developmental psychologist Ili Ma has been awarded an ERC grant to investigate misinformation among teenagers, aiming to bolster their resilience against its potentially severe consequences.
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FGGA experts on freedom: 'We are only truly free when everyone feels free'
On 5 May, we celebrate the liberation of the Netherlands in 1945 and the fact that we have been able to live in freedom ever since. But what does freedom mean, and how does it relate to our safety? Various FGGA experts draw connections with their own fields of expertise.
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A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits
Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…
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Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation
Source: PLoS ONE, Volume 10, Issue 3 (2015)
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How can we increase the financial sector’s resilience to cyber attacks? Get inside the mind of a hacker!
The financial sector is an appealing target for hackers. For that reason, lawmakers and regulators are going to great lengths to make the sector more resilient to cyber attacks. One recent measure was the introduction of the Digital Operational Resilience Act (DORA). This new EU regulation is extremely…
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NimbleAI
NimbleAI aims at solutions for ultra-energy efficient and secure neuromorphic sensing and processing at the edge.
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Cheminformatics: Analyzing small-molecule activity data
While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Host community compensation
Can the offering of host community compensation help to prevent or solve siting controversies, and if so, why and under which conditions?
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Quality-driven multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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A document classifier for medicinal chemistry publications trained on the ChEMBL corpus
Source: J Cheminform, Volume 6, Issue 1 (2014)
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Vision
The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.
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Editorial: Sanity and Resilience in Times of Corona
This editorial to RHCPP discusses how COVID-19 can be seen as a 'creeping crisis' according to the authors of its lead article (Boin et al, 2020) and how resilience may depend on the real heroes behind the scenes of response to disaster and adversity.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Why Leiden University
n an increasingly complex and security-challenged society, the CSM programme, Governance of Violence, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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Why Leiden University?
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Overview
The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors
Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)
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Organisation
Organisation of the Leiden Institute of Physics.
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Emergency contacts
What should you do in an emergency?
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Executive Board
The Executive Board is responsible for the management and administration of the entire University.
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Why Leiden University
In an increasingly complex and security-challenged society, the CSM programme, Intelligence and National Security, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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A blessing in disguise?! Discretion in the context of EU decision-making, national transposition and legitimacy regarding EU directives
This dissertation looks into the role of discretion granted by EU directives (Article 288 Treaty on Functioning of the European Union) in legislative decision-making and national transposition processes of these directives.
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Designing a sustainable future for the European Healthcare Sector
The project seeks to develop an eco-design framework for single-use medical devices and packaging
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Why Leiden University?
In an increasingly complex and security-challenged society, the CSM programme, Cybersecurity Governance, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Alternative delivery of a thermostable inactivated polio vaccine
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…
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Why Leiden University?
In an increasingly complex and security-challenged society, the CSM programme, Terrorism and Political Violence, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Extracellular Matrix Mechanics in the Regulation of the early steps of the Metastatic Cascade
Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.
