In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

We invite proposals for workshops and tutorials, to be held in Leiden on 01 July 2024 (deadline passed).

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

The Faculty of Science is housed in various buildings situated in the Bio Science Park Leiden.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Promotor: M.A.G.J. Orrit

General

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Software development is a complex process. It is important that software products become stable and maintainable assets.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Cody Bahir defended his thesis on 1 June 2017.

Under a sunny sky 44 teams completed the Leiden Science Run this weekend. They raised as much as 3450 euros for refugee-students’ association UAF.

On this page the programme and sessions can be found.

The Secular Outlook describes what moral and political secularism means. It paints the image of a world view in which state and religion are kept well separated.

Tracking early human behaviour through plant processing and -exploitation.

Leids onderzoek naar bestraffing komt tot stand uit verschillende disciplines. Het onderzoeksproject kent een juridische, criminologische, sociaalwetenschappelijke en filosofische invalshoek.

The Leiden Bio Science Park (LBSP) is eager for new talent. Therefore, as a member of the core group, Miranda van Eck is committed to improving cooperation between the faculty and the business community. How do we make sure we know how to find each other better? And how do we show our students what…

Green cities and a well-protected food system: Roy Remme and Oliver Taherzadeh study ways to achieve these. But how can their scientific findings lead to societal change? They share their experiences with science-policy initiatives.

Music, being together and the impact of science were at the heart of the festive opening of the academic year and the start of the faculty’s 200-year anniversary. The faculty was 200 years old on 2 August 2015. The anniversary was celebrated in style, attended by 500 members of staff and students.

The Dutch Research Council (NWO) has rewarded four projects in which Leiden researchers are bringing science and society closer together. What are these projects?

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Eleven researchers of the Faculty of Science are on the 2021 Highly Cited Researchers list of Clarivate Analytics. Only 0.1 per cent of researchers are included in this list, literally making them one in a thousand.

How can we help children and adults to acquire better reading comprehension? Paul van den Broek and his colleagues at the Brain and Education Lab are searching for an answer to this question by investigating reading and the related brain activity.

To what extent can contingent, formative feedback in lectures, facilitated by web-based ICT, increase students’ self-efficacy and (academic, behavioral, and cognitive) engagement? And how are self-efficacy and engagement influencing students’ performance and course evaluations?

ARC (art_research_convergence) is an outreach initiative of Leiden University Academy of Creative and Performing Arts, and the University of the Arts The Hague, for the active communication of artistic research.

The Leiden Centre for Continental Philosophy (LCCP) is a research community based at the Institute for Philosophy at Leiden University. LCCP is envisaged as an open space for stimulating discussion, critical debate and inventive co-operation in the local and international philosophical community. We…

This project tries to explain the persistence of this cultural repertoire by zooming in on (1) interaction between idioms (cultural repertoires) available to scholars at certain points in time, (2) mechanisms that help transmit repertoires across time and place, and (3) rhetorical purposes for which…

What role did inequality play in the past? On Friday 5 December, Master's students in history presented their answers at a conference they organised themselves.

...What does seem clear, though, is that there is a great deal of room for improvement in the process of out-of-home placement. The FSW's social and behavioural scientists give their views.

What are the characteristics of impactful education for student application of inclusive design principles in design and technology programs?