How can we view societal challenges from a different perspective? At the EuroScience Open Forum (ESOF), Robert Zwijnenberg, Emeritus Professor of Art and Science Interactions, will call for more collaboration between artists and scientists.

Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.

Minister of Justice Dilan Yeşilgöz-Zegerius recently warned against

What is the best living environment for dementia patients? To answer this question, Daniela Gawehns is using data mining methods to search through different types of data source. Her research is inadvertently building a bridge between two disciplines that are sometimes somewhat wary of each other.

Leiden will be scientific capital of Europe in 2022. The theme of the festivities was announce on 28 October: Who Knows. After all, does anyone have a monopoloy on wisdom these days? Who decides what is true? And does anyone actually know what the future holds?

Cody Bahir defended his thesis on 1 June 2017.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Westerdijkgarage, Johanna Westerdijkpad 12, 2342DJ, Oegstgeest

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: M.A.G.J. Orrit

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

The Faculty of Science is housed in various buildings situated in the Bio Science Park Leiden.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

We invite proposals for workshops and tutorials, to be held in Leiden on 01 July 2024 (deadline passed).

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

General

Software development is a complex process. It is important that software products become stable and maintainable assets.

Under a sunny sky 44 teams completed the Leiden Science Run this weekend. They raised as much as 3450 euros for refugee-students’ association UAF.

On this page the programme and sessions can be found.

Tracking early human behaviour through plant processing and -exploitation.

The Secular Outlook describes what moral and political secularism means. It paints the image of a world view in which state and religion are kept well separated.

Leids onderzoek naar bestraffing komt tot stand uit verschillende disciplines. Het onderzoeksproject kent een juridische, criminologische, sociaalwetenschappelijke en filosofische invalshoek.