This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

What drives the behaviour of accountability forums?

LiDAR, a laser-based remote sensing technology, is transforming archaeology by uncovering hidden landscapes beneath forests, vegetation, and shallow waters. Though initially designed for land management, its applications in archaeology have grown rapidly.

The routine assumption that Upper Palaeolithic early modern humans in Europe were regular fire users who produced fire at will has never been tested against the archaeological record. Utilizing literature, database and microwear analytical approaches, this project seeks to establish the role and forms…

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Investigating the making of knowledge in anthropology and natural history in colonial and postcolonial Indonesia.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

How do lecturer-researchers at Dutch Universities of Applied Sciences perceive their academic identity after expanding their teaching-only work portfolios to include researcher roles, and how do they navigate attached identity-based role transitions, while balancing personal goals, institutional expectations,…

In July 2023, Leiden University conducted another phase of its ongoing archaeological collaboration with the Kalinago Territory in the Caribbean island of Dominica. Activities focused on mapping and assessing coastal sites impacted by climate stressors, undertaking knowledge-exchange sessions, and co-creating…

Intelligence scholars have been struggling to find the conditions under which international intelligence cooperation occurs. Most focus on transactional motives and guaranteed returns, the so called ‘Quid pro Quo’. At the same time, trust is often mentioned as one of the foremost conditions, yet it…

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

From corpus pragmatics and metapragmatics to accountability and intentions, and from conversational structure and im/politeness to the role of emotions in utterance interpretation, the short articles collected here represent not just the wide scope of Michael's own work but also a snapshot of the field,…

In this article, Makszin developed a conceptual framework for the operating mission of an independent Central Bank and traced changes in the operating mission of the Hungarian National Bank over its recent 27-year history together with Sebők and Simons. This study aims to understand the dynamics of…

Bernard Bernards examines constraints on innovation by focusing on cognitive uncertainty as a personal state that may affect innovative work behavior.

Since 2012, thousands of individuals have traveled from Western countries to join jihadist groups in Syria and Iraq. While much has been written about these individuals, only sparse attention has been paid to the social environment of these jihadist travelers and, more specific, the role of family members…

How can the importance of the image in late medieval spirituality be understood in the context of the love mysticism inspired by the imagery of the Song of Songs?

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Industrial sites are built for safety, but are they prepared for security breaches? As concerns grow over threats to national security, these sites are a target. The Securdomino project built a tool to prevent malicious attacks and rethinks how we define security.

When we are in a conversation, how do we know exactly when to respond, and how do we manage to respond so swiftly, yet without interrupting our interlocutors? Can speech melody – in particular utterance final “boundary tones” – help us determine who will speak next, or are these cues too late in the…

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Scientists, including our faculty colleague Dr. Mike Field, studying an exceptionally well-preserved woolly rhinoceros have revealed details of what Britain's environment was like 42,000 years ago. The beast's remains were discovered in Staffordshire in 2002, buried alongside other preserved organisms…

On March 21 2018, a study was published in Nature, co-authored by Professor M. Soressi from the Faculty of Archaeology of Leiden University, announcing the sequencing of five new Neandertals, raising the number of high-coverage sequenced Neandertals from two to seven. A tooth lost by a Neandertal woman…

The use-wear analysis of domestic implements provided new insights of the Single Grave Culture population in the Netherlands.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

This study investigates how the tenure of security (proxied by both inter- and intra-party electoral advantage) affects the engagement and political performance of members of parliament.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

EUMOTIONS explores the role of emotions expressed by political elites (at EU- and member state-level) in framing the EU’s policy options during international crises.

Source: ChemMedChem (2015)

This article argues that opposition to government green investments is conditional on the method of financing.

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

A consortium led by Leiden University has been awarded 6.75 million euros to research traumascapes: physical places associated with collective trauma and loss. The research team aims to make these places more visible, accessible and inclusive.

Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.

Otrar as a Case Study for a 6-10th century Transition Zone

This project combines an extensive new open database on linguistic distributions, spatial modelling and areal linguistics in order to disentangle the roles of social and environmental factors on the emergence of linguistic diversity patterns of South America.

The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Campaign initiated at Generosity to cover the cost of construction.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

L1-oral language education is widely regarded as essential for developing communicative competence and critical thinking. However, as a research domain it remains relatively underexplored. The aim of this study was to identify effective elements and challenges within oral language education and to contribute…

How do governments distribute resources across economic sectors during a crisis? And why do some sectors receive more than others? The recent COVID-19 pandemic has highlighted the urgency of these questions. In this paper, we explore the extent to which a political economy…

How and when do interest groups organise themselves as transmission belts and what are the implications for their political relevance among public officials involved decision-making processes?