OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

When we are in a conversation, how do we know exactly when to respond, and how do we manage to respond so swiftly, yet without interrupting our interlocutors? Can speech melody – in particular utterance final “boundary tones” – help us determine who will speak next, or are these cues too late in the…

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

This project combines an extensive new open database on linguistic distributions, spatial modelling and areal linguistics in order to disentangle the roles of social and environmental factors on the emergence of linguistic diversity patterns of South America.

The 2006 United Nations Convention on the Rights of Persons with Disabilities differs markedly from other forms of international human rights law: it not only protects the rights of individuals but also addresses interpersonal relations and social structures. How did the convention attain this broad…

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

This study investigates how the tenure of security (proxied by both inter- and intra-party electoral advantage) affects the engagement and political performance of members of parliament.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

EUMOTIONS explores the role of emotions expressed by political elites (at EU- and member state-level) in framing the EU’s policy options during international crises.

Source: ChemMedChem (2015)

This article argues that opposition to government green investments is conditional on the method of financing.

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

To what extent are there differences between countries in and outside the European Union and the Schengen area in the level of crimmigration, the merger between migration control and crime control, and to what extent can these differences be explained by the way in which state and non-state actors in…

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

L1-oral language education is widely regarded as essential for developing communicative competence and critical thinking. However, as a research domain it remains relatively underexplored. The aim of this study was to identify effective elements and challenges within oral language education and to contribute…

How do governments distribute resources across economic sectors during a crisis? And why do some sectors receive more than others? The recent COVID-19 pandemic has highlighted the urgency of these questions. In this paper, we explore the extent to which a political economy…

How and when do interest groups organise themselves as transmission belts and what are the implications for their political relevance among public officials involved decision-making processes?

This study explores public leaders’ organizational learning orientation in the wake of a crisis. More precisely, we study the association between public leaders’ public service motivation and their learning orientation (instrumental versus political).

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

On 19 December 2019, Reza Eftekhar defended his thesis 'The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival of the Localisation Theory'. The doctoral research was supervised by Prof. E. de Brabandere.

On 7 November 2018, Catherine Harwood defended her thesis 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. The doctoral research was supervised by Prof. dr. L.J. Van den Herik and Prof.…

How have British cities changed in the years since the Second World War? And what drove this transformation? This innovative new history traces the development of the post-war British city, from the 1940s era of reconstruction, through the rise and fall of modernist urban renewal, up to the present-day…

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

This book aims to unravel some of the mysteries surrounding this exceptional group of larger-than-life Bronze Age blades.

Can epigenetic changes explain associations between early life stress and health outcomes?

The level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties.

In this article, Amandine Lerusse, investigates how the order of performance information affects local politicians’ issue prioritisation decisions.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.

In this conversation-analytic study, the authors analyze conversations between researchers from different disciplines and community members to examine relationship building in real life. This is an open access article under the Creative Commons By license.

The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…

Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.

This dissertation reports on the beliefs and perceptions of Chinese and Dutch university teachers regarding the role of research in university teaching and how these beliefs and perceptions can be explained by their cultural, institutional and individual background characteristics

The starting hypothesis of the project is that secrecy is not always inimical to democratic governance as conventional wisdom has it.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Source: Journal of Investigative Dermatology, Volume 134, pp. S44-S44 (2014) ISBN: 0022-202X

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

Drawing is one of the most unique human behaviours. Like language, drawing is a mode of communication and a cognitive tool that from an early age allows us to interact with others. Is the early development of drawing skill influenced by the social environment? If so, how?

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa