In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Leiden University is home to over a hundred specialists studying the Middle Ages and the Early Modern period. From 2017-2018 onwards, they will join forces to offer two new options for specialisation within existing MA programmes: Medieval Studies and Early Modern Studies.

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

On 10 June 2021, Merinda Stewart defended her thesis 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. The doctoral research was supervised by Prof. P.M.J. Mendes de Leon en Prof. J.J. Rijpma.

Promotor: M. Ubbink, Co-promotor: G. Siegal

With the recent rise and fall of IS, academics and policy makers around the world are expressing concerns about the fate of children of former foreign fighters. Will they follow in their parents’ footsteps? In this paper, Layla van Wieringen, Daan Weggemans and Marieke Liem argue that in light of this…

How do educational philosophies, discourses and practices spread around the globe, and how are they transformed and adapted locally?

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

This November, Leiden Jewish Studies Network has presented the Best Thesis in Jewish Studies award to a highly talented Leiden graduate, Lotte-Sofie Groenendijk, and awarded an honourable mention to Nasreen Javanjoo.

On Friday 7 March 2025 Adam Knight successfully defended a doctoral thesis and graduated.

Nederland heeft geen nationale bloem en daar wil het radioprogramma Vroege Vogels verandering in brengen. Verschillende experts van Universiteit Leiden zijn betrokken bij de verkiezing.

The Gravitation programme NETWORKS has been awarded a COFUND grant of 3 million euros. Half of this comes from the European Commission's Marie Skłodowska-Curie Actions programme, with industry partners paying the other half. Of the fourteen new PhD candidates, two will join Frank den Hollander's research…

On Tuesday 7 December, Wouter Kalf gave a lecture on how All Knowlegde starts with intuïtions for the Studium Generalis series co-hosted by the Museum de Lakenhal. The lecture was in Dutch.

What does the European Union mean for people living in Leiden? As part of the Leiden European Festival, and in collaboration with the municipality of Leiden, the city photographers captured Leidenaren from 28 European member states at their favorite place in the city. The exhibition will travel along…

On Wednesday 14 May 2025 Remzi Çakırlar successfully defended a doctoral thesis and graduated.

The Board of Governors of Leiden University has confirmed the appointment of Professor André Gerrits (Institute for History, currently in the field of Russian Politics and History) to the field of International Studies and Global Politics, commencing October 1st 2015.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

The urban graveyard presents several studies in which the results of older archaeological and osteoarchaeological research are compared to more recent excavation data from several Dutch, Belgian and Danish cities and towns.

On Tuesday 3 September 2024 Straton Papagianneas successfully defended a doctoral thesis and graduated.

On Friday 22 November 2024 Ye Jiang successfully defended a doctoral thesis and graduated.

Organised in four separate sessions throughout the day, and broadcast live online to guests and families who could not join, a total of 260 students received their Bachelor’s Diploma of International Studies on 28 August 2020 at the graduation ceremony in the historic Pieterskerk in Leiden.

On the 26th of September, Cosmas Rai Amenorvi successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Cosmas on this achievement!

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

An archaeological case-study of the Pointe des Châteaux, La Désirade and Les Îles de la Petite Terre micro-region, Guadeloupe, F.W.I.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

This article by Honorata Mazepus and Florian van Leeuwen in the journal Governance: An International Journal of Policy, Administration and Institutions looks at how evaluations of authorities were influenced by four aspects of a governmental response to a hypothetical disaster.

How do Humanitarian Response Organizations (HROs) and Virtual & Technical Communities (V&TCs) collaboratively govern disaster sensemaking processes, and what challenges shape the effectiveness of these collaborations between 2010 and 2016?

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…