Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

COUNTERRR examines domestic responses to jihadist armed groups in Africa, analyzing variation in state repression, community resistance, and the evolution of security across Mali, Nigeria, and Mozambique.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This project aims at describing the Khoisan languages !Ora (Korana/Griqua) and !Ui of South Africa.

Abbas provides an in-depth analysis of the complex interplay between Zionism, Jewish identity, power dynamics, and the Israeli-Palestinian conflict.

Can we link multiple components from herbal extracts with their biological activities?

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

What is the relation between the experience and the act of exclusion?

What is the role of the noradrenergic system in human cognition?

On 8 June, Wanlu Zhang defended the thesis 'Protection of aviation security through the establishment of prohibited airspace'. The doctoral research was supervised by Steven Truxal and Robert Heinsch.

Research on the process and construction of news stories about human rights issues in Latin American newspapers.

The authors of the article expect automation to improve accuracy in less complex programmes but worsens with increased complexity

All PhD candidates who started their project in 2019 or later take a mandatory course on academic integrity, preferably in their first year.

This research investigates the impact of socioeconomic developments on the physical condition of medieval populations in Holland and Zeeland between AD 1000 and 1600 through the analysis of human skeletal remains from three archaeological sites.

The Caribbean Research Group has recently been involved in fieldwork on two sites on St Vincent. Firstly Brighton Beach, and secondly Argyle.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Leiden University is established in two cities: Leiden and The Hague.

Leiden Law School is currently housed in two beautifully restored historic buildings located in the old centre of Leiden. We also have facilities for teaching and research at Campus Den Haag.

Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.

The authors explore the decision-making processes and debates surrounding EU member states' troop contributions to CSDP military deployments.

On 9 November, Roosmarijn van Es defended the thesis 'The mind in the courtroom: on forensic mental health reports in judicial decision-making about guilt and sentencing in the Netherlands. The doctoral research was supervised by Jan de Keijser, Maarten Kunst and Janne van Doorn.

Children with autism spectrum disorder experience serious challenges in social functioning, which threatens their development in many areas of functioning.

Mission statement

The present study explores the role of water in the ancient Roman city of Ostia.In antiquity, Ostia was situated at the intersection of the Tiber River and the Mediterranean Sea, and acted as one of the harbour cities of Rome for several centuries.This study investigates how water was acquired, used,…

How do mycobacteria subvert the defenses of host immune cells?

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Central to this research is the Urban Future-project, which consists of a large archive of artworks made from 2002 until now.

El pueblo Kamëntšá en la encrucijada del patrimonio cultural

How have the armed forces of the United Kingdom, the Netherlands and Belgium adapted to the OMLT task in Afghanistan, and what institutional changes have materialised as a consequence of this adaptation?

The Graduate School of Social and Behavioural Sciences in collaboration with the Department of Methodology and Statistics and researchers in the field of Methodology and/or Statistics of the other Institutes provides training courses for PhD candidates and other researchers.

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.

ASLU (Archaeological Studies Leiden University) is a peer-reviewed book series produced by the Faculty of Archaeology, Leiden University.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Annemarie van Stee defended her thesis on 21 June 2017.

What are the mechanisms involved in the reconciliation of value conflicts and which interventions are capable of resolving such disputes?

What was the nature of the urban network in the Roman provinces of Germania Superior, Raetia and Noricum and how stood this in relation with economic and social developments?

Until 2019, LUCIS organised an annual conference to highlight state-of-the-art research on a central theme within the academic study of Islam and society. Researchers from around the globe convened in Leiden to share and discuss their work.

Barbarism: from the 18th century to the present.

From junior school pupils to university students: the Living Lab is a valuable place of study for many people. Every year the Living Lab trains dozens of students at vocational, college and university level. More than a thousand pupils also have lessons on location, and junior schools use over thirty…

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

This study tests whether behavioural problems at a young age are related to early reading and mathematics development.

Trajectories of social life in the yucayeque (community) of El Cabo, Higüey, Dominican Republic, AD 800 to 1504

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Previous studies have identified institutional, organizational, and individual factors that promote innovation in public organizations. Yet they have overlooked how the type of public administration—and the type of administrators—is associated with innovative attitudes.