Throughout the world fundamental labour rights in supply chains are being violated. Since the Rana Plaza disaster in Bangladesh shook the world, we can no longer turn our heads away.

On Thursday 28 September, the Committee on Social Minimum, of which Koen Caminada is a member, presented its second report to outgoing minister for poverty policy in the Netherlands, Carola Schouten. The Committee was established by the minister at the request of the House of Representatives.

AI MAPS adopts a freedom and social well-being perspective and focuses on three themes to address key security challenges; Social disorder and public nuisances in neighbourhoods, High-impact crime, and Crowds and events.

It’s been a turbulent, bizarre and extraordinary year, 2020. Coronavirus turned the lives of everyone at our University upside down. Out teaching, research and all the events that are held in a year: nothing was the same as before. That this affected all of us is clear from the highlights and many reactions…

Africa is online. Leiden Africa expert Mirjam de Bruijn is fascinated by the fast development of mobile telephony and social media in Africa. She maintains a website on the topic, focusing on isolated, marginalised and conflict-ridden areas in Middle Africa.

On 4 and 5 September, Leiden Law School hosted a special conference that brought together around sixty participants from the Netherlands and abroad to discuss the future of economic, social, and cultural rights – rights that touch upon everyone’s daily life: housing, education, healthcare, food, and…

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Nederlandse bedrijven repatriëren medewerkers uit het Midden-Oosten vanwege oplopende spanningen in dat gebied. Verschillende juristen, waaronder hoogleraar arbeidsrecht Yvonne Erkens, wijzen in het FD op de verantwoordelijkheid van werkgevers in situaties als deze

PhD defence

In June the Final Festival took place, the closing event of the 'Social Science Lab'. New participants of Honours College Science and Society presented their solution for a current social problem.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

This project investigates how robot testing facilities could help to optimize the regulation for robot technologies.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Supervisor: Natalia Ortiz Zacarías

Compare human social behaviour at a country level and you will find differences. Japan has the highest score whereas the Netherlands is just above average. This is what psychologist Niels van Doesem discovered in research with an international team of 64 colleagues in 31 industrialised countries. Their…

Nowadays children grow up with social media. This may influence the development of brain regions involved in social interaction. In their review article in Nature Communications, Crone and Konijn illustrate how neuroscience can contribute to a better understanding of how media and peers influence adolescents'…

The annual homicide rate has decreased considerably since the 1990s. In their hunt for an explanation, researchers Pauline Aarten and Marieke Liem made a surprising discovery: if you divide homicides into categories, you find significant differences in the homicide rate. Publication in the European…

Leiden University has a new Executive Board. Since 8 February 2021, Annetje Ottow has been the new President and Hester Bijl the new Rector Magnificus of the Board, while Martijn Ridderbos has continued in his role as Vice-Chairman.

Would you like to know more about our research using laboratory animals or our studies on alternatives to animal testing? If so, take a look at the news articles on the right-hand side of the page (for mobile users, see the bottom of the page).

Promotores: J. Jonkers, K.E. de Visser

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Source: J Med Chem (2015)

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

A 5 million euros grant from the Dutch Research Agenda allows Anouk de Koning and co-applicants Femke Kaulingfreks and Maartje van der Woude to study social interventions in eight Dutch cities in an innovative and interdisciplinary way.

ERC StG SAFE and SOUND has the ambition to connect the policy cycle with data generated in robot testing zones to support evidence-based policymaking for robot technologies.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…