Last Monday April 18, Bram Koster (professor at the Institute of Biology Leiden (IBL), professor at the Leiden University Medical Center (LUMC)) and Ariane Briegel (professor at the IBL) gave a presentation to the mayor of Leiden, Henri Lenferink. The presentation took place at NeCEN, the open access…

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Life Science and Technology. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either a biomedical, molecular or biophysical approach…

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

On the 5th of April 2019 our dear colleague and friend Professor Dr Mathieu Noteborn has passed away. In January of this year he was diagnosed with bowel cancer. He underwent surgery followed by chemotherapy, and despite the invasive nature of this therapy things were looking up. True to his optimistic…

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

When you apply for admission, you’ll be asked to submit several documents.

The Leiden Institute of Chemistry actively participates in several national research schools for MSc and PhD students. These schools are consortia that stimulate collaboration between research groups of the different participating Dutch universities. The research schools also offer advanced training…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

What are the phylogenetic relationships among the members of speciation bursts?

When the tokay gecko loses its tail, a new one grows from resident stem cells at the stump. Each tissue type - muscle, bone, blood vessels and skin - develops from specific stem cells. This discovery by Luthfi Nurhidayat holds potential implications for advancing regenerative medicine in humans. Nurhidayat…

‘Make more room for nature on farmland and you'll be surprised at the result.' This was the advice from Geert de Snoo in his Dies lecture.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.

Using E. coli bacteria to convert a toxic compound in the soil on Mars into oxygen to make life on the planet possible. A team of thirteen Leiden students are taking part in the annual iGEM competition with an entry based on this idea. iGEM is an international competition for students where they use…

Short description about 20th anniversary of CEDC, the fieldstation in Cameroon, and 20 years of cooperation between Leiden University with the University of Dschang in Cameroon.

The Rob Schilperoort Memorial will be unveiled at the Leiden Bio Science Park on Saturday 16 September. This gigantic gate stands at the entrance to the park, which is also named after Schilperoort, its founder.

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: J. Schaye

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: Prof.dr. E.F. van Dishoeck, Co-promotor: S. Bruderer

Promotor: Prof.dr. P.C. van Welzen

Source: ChemMedChem (2015)

Find out how to apply for Molecular Genetics and Biotechnology at Leiden University by following our step-by-step guide.

Lecture

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Despite the field’s general agreement that pyrotechnology had a significant impact on the cultural evolution of humankind, our understanding of the origins and development of fire use and its role in humankind’s cultural evolution is very limited, blurred by strong disagreements over its chronology…

The application procedure is divided into four parts.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

To be eligible for Molecular, Cellular and Organismal Biology at Leiden University, you must meet the following admission requirements.

A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.

‘Wadden Sea Sounds’ is the name of a new project launched by the Waddenvereniging in collaboration with researchers from Leiden University and the University of Groningen. The aim is to find out how underwater noise affects marine life in the Wadden Sea.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…